アジュバント関節炎ラットにおける超音波発信反応の痛み評価への応用
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概要
- 論文の詳細を見る
Adjuvant-induced arthritic (AIA) rats develop a severe chronic polyarthritis which shares some features in common with human rheumatoid arthritis. The purpose of the present study was to examine whether AIA rats emit ultrasonic vocalizations (USVs) when they are confronted with a healthy `stimulus rat in social interactions. We also examined the effects of three analgesic drugs (piroxicam, rofecoxib and ketoprofen) on USV responses using the same paradigm. In social interactions, AIA rats and intact controls emitted USVs in the 22-28 kHz range. Vocalization activities were significantly higher in AIA rats than those in intact controls. Moreover, the USVs of AIA rats were significantly inhibited by the three analgesic drugs. These results suggest that the USV responses elicited in AIA rats are useful for the evaluation of analgesic drugs.
- 社団法人 日本実験動物学会の論文
- 2006-04-01
著者
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SUZUKI Yoshihiko
Department of Toxicology, Azabu University School of Veterinary Medicine
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NAITO Hiroyuki
Department of Physics, Nagoya University
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INOUE Maki
Department of Physiology II, Azabu University
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Inoue Maki
Department Of Neurophysiology School Of Veterinary Medicine Azabu University
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Naito Hiroyuki
Department Of Neurophysiology School Of Veterinary Medicine Azabu University
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内藤 博之
Department of Physiology , School of Veterinary Medicine, Azabu University
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井上 真紀
Department of Physiology , School of Veterinary Medicine, Azabu University
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Inoue Maki
Department Of Neurophysiology
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OKUMURA Takako
Discovery Biology Research, Nagoya Laboratories, Pfizer Global Research and Development, Pfizer Inc.
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Suzuki Y
Department Of Biochemistry School Of Veterinary Medicine Azabu University
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Suzuki Yoshihiko
Seis Project Technology Research Institute Of Osaka Prefecture
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Okumura Takako
Discovery Biology Research Global Research & Development Nagoya Laboratories Pfizer Japan Inc.
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Okumura Takako
Discovery Biology Research Nagoya Laboratories Pfizer Global Research And Development Pfizer Inc.
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Suzuki Yoshihiko
Department Of Biochemistry School Of Veterinary Medicine Azabu University
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Suzuki Yoshihiko
Department Of Biochemistry And Cell Biology Institute Of Development And Aging Sciences Graduate Sch
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奥村 貴子
Discovery Biology Research, Nagoya Laboratories, Pfizer Global Research and Development, Pfizer Inc.
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