アジュバント関節炎ラットの超音波発信反応を指標とする鎮痛薬薬効試験法の検討
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概要
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Adjuvant-induced arthritic (AIA) rats have been developed as a chronic pain model to evaluate the effects of analgesic drugs. The purpose of the present study was to examine whether there is dose-dependent inhibition of the emission of ultrasonic vocalization (USV) responses by analgesic drugs in AIA rats. It was demonstrated that morphine (1.25-5.0 mg/kg, s.c.) and ketoprofen (2.5-10.0 mg/kg, s.c.) dose-dependently inhibit USV responses. These results suggest that the USV responses elicited in AIA rats are useful for the quantitative evaluation of analgesic drugs.
- 社団法人 日本実験動物学会の論文
著者
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内藤 博之
麻布大学獣医学部
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井上 真紀
麻布大学獣医学部
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NAITO Hiroyuki
Department of Physics, Nagoya University
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INOUE Maki
Department of Physiology II, Azabu University
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Naito Hiroyuki
Department Of Neurophysiology School Of Veterinary Medicine Azabu University
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内藤 博之
Department of Physiology , School of Veterinary Medicine, Azabu University
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井上 真紀
Department of Physiology , School of Veterinary Medicine, Azabu University
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Inoue Maki
Department Of Neurophysiology
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NAITO Hiroyuki
Department of Physiology , School of Veterinary Medicine, Azabu University
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