Effect of Anxiolytic Drugs on Air-Puff-Elicited Ultrasonic Vocalization in Adult Rats
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概要
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Ultrasonic vocalization (USV) responses elicited by air-puff stimuli were compared in regard to both quality and quantity with those elicited by electric foot-shock(s) in adult rats. Frequency pattern, duration, repetition rate and interpulse interval of air-puff-elicited USV were comparable to those observed on foot-shock-elicited USV. Diazepam (0.25-1.0 mg/kg, s.c.) and buspirone (0.1-1.0 mg/kg, s.c.) attenuated equally and dose-dependently the USV responses elicited by both aversive stimuli. Air-puff-elicited USV was specifically attenuated in a dose-dependent manner by the anxiolytic properties of several psychotropic agents: diazepam (1.0-10.0 mg/kg, p.o.), buspirone (10.0-100.0 mg/kg, p.o.), 8-OH-DPAT (0.01-0.5 mg/kg, s.c.). Haloperidol (0.2-1.0 mg/kg, s.c.) weakly attenuated the USV response. Imipramine (0.2-1.0 mg/kg, s.c.) which has no anxiolytic property had no effect. Consequently, air-puff-elicited USV as well as foot-shock-elicited USV may provide a reliable tool for the study of anxiety.
- 社団法人 日本実験動物学会の論文
- 2003-10-01
著者
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SUZUKI Yoshihiko
Department of Toxicology, Azabu University School of Veterinary Medicine
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NAITO Hiroyuki
Department of Physics, Nagoya University
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INOUE Maki
Department of Physiology II, Azabu University
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Inoue Maki
Department Of Neurophysiology School Of Veterinary Medicine Azabu University
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Naito Hiroyuki
Department Of Neurophysiology School Of Veterinary Medicine Azabu University
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Inoue Maki
Department Of Neurophysiology
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NAKAMURA Amane
Department of Neurophysiology, School of Veterinary Medicine, Azabu University
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Suzuki Y
Department Of Biochemistry School Of Veterinary Medicine Azabu University
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Suzuki Yoshihiko
Seis Project Technology Research Institute Of Osaka Prefecture
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Nakamura Amane
Department Of Neurophysiology School Of Veterinary Medicine Azabu University
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Suzuki Yoshihiko
Department Of Biochemistry School Of Veterinary Medicine Azabu University
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Suzuki Yoshihiko
Department Of Biochemistry And Cell Biology Institute Of Development And Aging Sciences Graduate Sch
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Inoue Maki
Department of Ecosystem Studies, Institute of Agricultural and Life Science, The University of Tokyo
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INOUE Maki
Department of Animal Science, Faculty of Agriculture, Kyoto University
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