Effect of Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on the Susceptibility to Listeria Infection(Food & Nutrition Science)
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概要
- 論文の詳細を見る
We studied the effect of lactational exposure to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on the susceptibility to Listeria infection of offspring in C57BL/6NCji mice. The offspring were nursed by TCDD-treated dams and exposed to TCDD from birth to weaning via milk. The exposure had little effect on the weights of immune organs and the spleen or the thymus cell population in the dams and offspring, but it enhanced the production of tumor necrosis factor alpha (TNF-α) and interferon gamma (IFN-γ) in the serum after Listeria infection. The clearance of Listeria monocytogenes from the spleen was impaired in the offspring. These results suggest that the exposure to TCDD of the offspring via milk disrupted the host resistance of the offspring, even though the main immune parameters were unchanged.
- 社団法人日本農芸化学会の論文
- 2003-01-23
著者
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SUZUKI Yoshihiko
Department of Toxicology, Azabu University School of Veterinary Medicine
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NAITO Hiroyuki
Department of Physics, Nagoya University
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Suzuki Y
Department Of Applied Biological Chemistry The University Of Tokyo
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Suzuki Yoshihito
Dep. Of Applied Biological Chemistry Univ. Of Tokyo
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Naito H
Medicinal Chemistry Research Laboratory Daiichi Pharmaceutical Co. Ltd.
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Naito Hiroyuki
Department Of Neurophysiology School Of Veterinary Medicine Azabu University
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Naito Hiroyuki
Department Of Veterinary Science Azabu University
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KOBAYASHI Kazuo
Division of Toxicology, Biological Safety Research Center, National Institute of Hygienic Sciences
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Suzuki Y
Department Of Global Epidemiology Hokkaido University Research Center For Zoonosis Control
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Sugita-konishi Yoshiko
Division Of Microbiology National Institute Of Health Sciences
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Sugita-konishi Yoshiko
Department Of Veterinary Science Azabu University
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Suzuki Yoshikatsu
Riken (the Institute Of Physical And Chemical Research)
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Suzuki Yoshihito
The Institute Of Enology And Viticulture Yamanashi University
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Suzuki Y
Research Institute For Bioresources Okayama University
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MIURA Katuhiro
Department of Safety Research, National Institute of Animal Health
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Kobayashi K
Division Of Microbiology National Institute Of Health Sciences
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Miura Katuhiro
Department Of Safety Research National Institute Of Animal Health
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Miura Katuhiro
Department Of Animal Husbandry Faculty Of Agriculture Tohoku University
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Suzuki Yoshihiko
Department Of Biochemistry School Of Veterinary Medicine Azabu University
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Kobayashi Kazuo
Division Of Cardiology Gunma Prefectural Cardiovascular Center
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Suzuki Yoshihiko
Department Of Biochemistry And Cell Biology Institute Of Development And Aging Sciences Graduate Sch
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Suzuki Yasushi
Department Of Agricultural Chemistry The University Of Tokyo
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