Marked Production of Ginsenosides Rd, F_2, Rg_3, and Compound K by Enzymatic Method
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概要
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The hydrolysis of protopanaxadiol-type saponin mixture by various glycoside hydrolases was examined. Among these enzymes, crude preparations of lactase from Aspergillus oryzae, β-galactosidase from A. oryzae, and cellulase from Trichoderma viride were found to produce ginsenoside F_2[3-O-(β-D-glucopyranosyl)-20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol], compound K[20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol], and ginsenoside Rd{3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol}, respectively, from protopanaxadiol-type saponin mixture in large quantities. Moreover, the crude preparation of lactase from Penicillium sp. having a high producing activity of ginsenoside Rh_1(6-O-β-D-glucopyranosyl-20(S)-protopanaxatriol) from protopanaxatriol-type saponin mixture gave ginsenoside Rd as a main product, ginsenoside Rg_3 {3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-20(S)-protopanaxadiol}, and compound K from protopanaxadiol-type saponin mixture. The hydrolytic pathways of ginsenosides Rb_1, Rb_2, and Rc to ginsenosides Rd, Rg_3, and F_2, and compound K by crude preparations of four glycoside hydrolases were also studied. This is the first report on the enzymatic preparation of an intestinal bacterial metabolite, ginsenoside F_2, in quantity, and a considerable amount of a minor saponin, ginsenoside Rg_3, from a protopanaxadiol-type saponin mixture.
- 公益社団法人日本薬学会の論文
- 2007-10-01
著者
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鈴木 和美
Showa College of Pharmaceutical Sciences
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Suzuki Kazutoshi
放射線医学総合研究所分子イメージング研究センター
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Suzuki K
Pharmaceutical Frontier Research Laboratories Japan Tobacco Inc.
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Suzuki Kenji
Suntory Institute For Biomedical Research Wakayamadai
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Choi Kang-ju
Kt & G Central Research Institute
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Choi Kang-ju
Korea Ginseng And Tobacco Research Institute
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Suzuki K
Noda Research Laboratories Drug Delivery System Institute Ltd.:(present Address)pharmaceutics Resear
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Suzuki Y
Department Of Applied Biological Chemistry The University Of Tokyo
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Suzuki Yoshihito
Dep. Of Applied Biological Chemistry Univ. Of Tokyo
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Kato Shingo
Research Center Hospital For Charged Particle Therapy National Institute Of Radiological Sciences
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KO Sung-Ryong
Korea Ginseng and Tobacco Research Institute
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KO Sung-Ryong
KT & G Central Research Institute
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SUZUKI Yukio
Okayama University
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SUZUKI Kei
Okayama University
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CHOI Kang-Ju
KT & G Central Research Institute
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CHO Byung-Goo
KT & G Central Research Institute
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Suzuki Y
Department Of Global Epidemiology Hokkaido University Research Center For Zoonosis Control
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Sugita-konishi Yoshiko
Department Of Veterinary Science Azabu University
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Suzuki Kazutoshi
Department Of Medical Imaging National Institute Of Radiological Sciences
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Suzuki Kazutoshi
Clinical Neuroimaging Section Department Of Molecular Neuroimaging Molecular Imaging Center National
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Suzuki Yoshikatsu
Riken (the Institute Of Physical And Chemical Research)
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Suzuki Yoshihito
The Institute Of Enology And Viticulture Yamanashi University
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Cho Byung-goo
Kt & G Central Research Institute
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Choi Kangju
Kt & G Central Research Institute
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Suzuki Y
Research Institute For Bioresources Okayama University
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Suzuki K
Molecular Imaging Center National Institute Of Radiological Sciences
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Ko Sungryong
Kt & G Central Research Institute
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Suzuki Yasushi
Department Of Agricultural Chemistry The University Of Tokyo
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