Marked Production of Ginsenosides Rd, F_2, Rg_3, and Compound K by Enzymatic Method

スポンサーリンク

概要

• 論文の詳細を見る

• The hydrolysis of protopanaxadiol-type saponin mixture by various glycoside hydrolases was examined. Among these enzymes, crude preparations of lactase from Aspergillus oryzae, β-galactosidase from A. oryzae, and cellulase from Trichoderma viride were found to produce ginsenoside F_2[3-O-(β-D-glucopyranosyl)-20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol], compound K[20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol], and ginsenoside Rd{3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol}, respectively, from protopanaxadiol-type saponin mixture in large quantities. Moreover, the crude preparation of lactase from Penicillium sp. having a high producing activity of ginsenoside Rh_1(6-O-β-D-glucopyranosyl-20(S)-protopanaxatriol) from protopanaxatriol-type saponin mixture gave ginsenoside Rd as a main product, ginsenoside Rg_3 {3-O-[β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl]-20(S)-protopanaxadiol}, and compound K from protopanaxadiol-type saponin mixture. The hydrolytic pathways of ginsenosides Rb_1, Rb_2, and Rc to ginsenosides Rd, Rg_3, and F_2, and compound K by crude preparations of four glycoside hydrolases were also studied. This is the first report on the enzymatic preparation of an intestinal bacterial metabolite, ginsenoside F_2, in quantity, and a considerable amount of a minor saponin, ginsenoside Rg_3, from a protopanaxadiol-type saponin mixture.

• 公益社団法人日本薬学会の論文
• 2007-10-01

著者

• 鈴木 和美

  Showa College of Pharmaceutical Sciences

• Suzuki Kazutoshi

  放射線医学総合研究所分子イメージング研究センター

• Suzuki K

  Pharmaceutical Frontier Research Laboratories Japan Tobacco Inc.

• Suzuki Kenji

  Suntory Institute For Biomedical Research Wakayamadai

• Choi Kang-ju

  Kt & G Central Research Institute

• Choi Kang-ju

  Korea Ginseng And Tobacco Research Institute

• Suzuki K

  Noda Research Laboratories Drug Delivery System Institute Ltd.:(present Address)pharmaceutics Resear

• Suzuki Y

  Department Of Applied Biological Chemistry The University Of Tokyo

• Suzuki Yoshihito

  Dep. Of Applied Biological Chemistry Univ. Of Tokyo

• Kato Shingo

  Research Center Hospital For Charged Particle Therapy National Institute Of Radiological Sciences

• KO Sung-Ryong

  Korea Ginseng and Tobacco Research Institute

• KO Sung-Ryong

  KT & G Central Research Institute

• SUZUKI Yukio

  Okayama University

• SUZUKI Kei

  Okayama University

• CHOI Kang-Ju

  KT & G Central Research Institute

• CHO Byung-Goo

  KT & G Central Research Institute

• Suzuki Y

  Department Of Global Epidemiology Hokkaido University Research Center For Zoonosis Control

• Sugita-konishi Yoshiko

  Department Of Veterinary Science Azabu University

• Suzuki Kazutoshi

  Department Of Medical Imaging National Institute Of Radiological Sciences

• Suzuki Kazutoshi

  Clinical Neuroimaging Section Department Of Molecular Neuroimaging Molecular Imaging Center National

• Suzuki Yoshikatsu

  Riken (the Institute Of Physical And Chemical Research)

• Suzuki Yoshihito

  The Institute Of Enology And Viticulture Yamanashi University

• Cho Byung-goo

  Kt & G Central Research Institute

• Choi Kangju

  Kt & G Central Research Institute

• Suzuki Y

  Research Institute For Bioresources Okayama University

• Suzuki K

  Molecular Imaging Center National Institute Of Radiological Sciences

• Ko Sungryong

  Kt & G Central Research Institute

• Suzuki Yasushi

  Department Of Agricultural Chemistry The University Of Tokyo

関連論文

• CT-based 3D Dose-Volume Parameter of the Rectum and Late Rectal Complication in Patients with Cervical Cancer Treated with High-Dose-Rate Intracavitary Brachytherapy
• A Convenient Synthesis of Tertiary Amines by Alkylation of Secondary Amines with Alkyl Halides in the Presence of Potassium Hydride and Triethylamine
• Stereoselective Introduction of Oxygen Functionalities at the 11β-Position of Erythrinan Skeleton : Total Syntheses of (±)-Erythristemine and (+)-Erythrartine
• Carbon Ion Radiotherapy : Clinical Experiences at National Institute of Radiological Science (NIRS)
• Isolation and Identification of (-)-Jasmonic Acid from Wild Rice, Oryza officinalis, as an Antifungal Substance(Organic Chemistry)
• Expression analysis of nitric oxide synthesis related gene in Lotus japonicus
• Symbiotic Rhizobium and Nitric Oxide Induce Gene Expression of Non-symbiotic Hemoglobin in Lotus japonicus
• Co-Regulation of Brassinosteroid Biosynthesis-Related Genes During Xylem Cell Differentiation
• Expression Pattern of the CsPK3 Auxin-Responsive Protein Kinase Gene
• CL-P1, a Newly Cloned Endothelial Cell Specific Scavenger Receptor
• Identification of a Peptide Mimic of Bioactive Gibberellins with Affinity to GA 2-Oxidase
• Sequential Regulation of Gibberellin, Brassinosteroid, and Jasmonic Acid Biosynthesis Occurs in Rice Coleoptiles to Control the Transcript Levels of Anti-Microbial Thionin Genes
• Identification of a Novel factor, Vanillyl Benzyl Ether, Which Inhibits Somatic Embryogenesis of Japanese Larch (Larix leptolepis Gordon)
• Brassinazole, an Inhibitor of Brassinosteroid Biosynthesis, Inhibits Development of Secondary Xylem in Cress Plants (Lepidium sativum)
• Biological Evaluation of 5-Substituted Pyrimidine Derivatives as Inhibitors of Brassinosteroid Biosynthesis
• EFFECT OF BRASSINOSTEROID ON PLANT DEFENSE RESPONSE AGAINST PATHOGENS
• ISOLATION OF BRASSINOSTEROID DEFICIENCY-INSENSITIVE MUTANTS OF ARABIDOPSIS
• Chlorophyll-deficient Mutants of Rice Demonstrated the Deletion of a DNA Fragment by Heavy-ion Irradiation
• The Effects of Carbon Ion Irradiation Revealed by Excised Perforated Intestines as a Late Morbidity for Uterine Cancer Treatment
• PCR Cloning and Expression of the F/10 Family Xylanase Gene from Streptomyces olivaceoviridis E-86
• Haplotype analysis of the human collectin placenta 1 (hCL-P1) gene
• N-Cyanomethyl-2-chloroisonicotinamide Induces Systemic Acquired Resistance in Arabidopsis without Salicylic Acid Accumulation(Organic Chemistry)
• Chloroisonicotinamide Derivative Induces a Broad Range of Disease Resistance in Rice and Tobacco
• SNA-60-367 Components, New Peptide Enzyme Inhibitors of Aromatase : Structure of the Fatty Acid Side Chain and Amino Acid Sequence by Mass Spectrometry
• Propeptin, a New Inhibitor of Prolyl Endopeptidase Produced by Microbispora : II. Determination of Chemical Structure
• New Types of Liposidomycins Produced by Streptomyces that Inhibit Bacterial Peptidoglycan Synthesis Structure Elucidation of Fatty Acid Components by Tandem Mass Spectrometry
• Structural Analyses of Carbon Chains in 5-Alk(en)ylresorcinols of Rye and Wheat Whole Flour by Tandem Mass Spectrometry
• Thiadiazole carboxylic acid moiety of tiadinil, SV-03, induces systemic acquired resistance in tobacco without salicylic acid accumulation
• Salicylic Acid-Mediated Cell Death in the Arabidopsis len3 Mutant
• Identification of Three Clones Which Commonly Interact with the Kinase Domains of Highly Homologous Two Receptor-Like Kinases, RLK902 and RKL1
• Molecular Characterization of Two Highly Homologous Receptor-like Kinase Genes, RLK902 and RKL1, in Arabidopsis thaliana
• Pyrazolecarboxylic Acid Derivative Induces Systemic Acquired Resistance in Tobacco(Biochemistry & Molecular Biology)
• Synthesis of a Novel Class of Polyhydroxyalkanoates in Arabidopsis Peroxisomes, and Their Use in Monitoring Short-Chain-Length Intermediates of β-Oxidation
• Quantitative analysis of dopamine transporters in human brain using [^C]PE2I and positron emission tomography : evaluation of reference tissue models
• Synthesis of ^C-Labelled Bis (phenylalkyl) amines and Their in Vitro and in Vivo Binding Properties in Rodent and Monkey Brains (Medicinal Chemistry)
• Synthesis and Brain Regional Distribution of [^C]NPS 1506 in Mice and Rat: an N-Methyl-D-aspartate (NMDA) Receptor Antagonist(Medicinal Chemistry)
• A Prodrug of NMDA/Glycine Site Antagonist, L-703, 717, with Improved BBB Permeability : 4-Acetoxy Derivative and Its Positron-Emitter Labeled Analog
• Production of Polyhydroxybutyrate by Polycistronic Expression of Bacterial Genes in Tobacco Plastid
• An Ergosterol Peroxide, a Natural Product That Selectively Enhances the Inhibitory Effect of Linoleic Acid on DNA Polymerase β
• Galactosyldiacylglycerol, a Mammalian DNA Polymerase α-Specific Inhibitor from a Sea Alga, Petalonia bingbamiae
• The Cyanogenic Glucoside, Prunasin (D-Mandelonitrile-β-D-Glucoside), Is a Novel Inhibitor of DNA Polymerase β
• Action of a New Mammalian DNA Polymerase Inhibitor, Sulfoquinovosyldiacylglycerol
• Correlation between the Physicochemical Property of Some Nonsteroidal Anti-inflammatory Drugs and Changes in Adenosine Triphosphate, Glutathione and Hemoglobin in Rat Erythrocytes(Biopharmacy)
• Identification and Characterization of a Novel Human Collectin CL-K1
• Molecular Cloning of Mouse Collectin Liver 1(Biochemistry & Molecular Biology)
• Effects of Partial Suppression of Ribosomal Protein S6 on Organ Formation in Arabidopsis thaliana(Biochemistry & Molecular Biology)
• Enzymatic Synthesis of Two Ginsenoside Re-β-xylosides
• Transglycosylation to Ginseng Saponins by Cyclomaltodextrin Glucanotransferases
• Purification and Characterization of Recombinant Mortierella vinacea α-Galactosidases I and II Expressed in Saccharomyces cerevisiae
• Effects of Aspirin and/or Salicylate on Hydrolysis and Glucuronidation of Indomethacin in Rat Erythrocytes and Hepatocytes
• Resistance to Protoporphyrinogen Oxidase-inhibiting Compound S23142 from Overproduction of Mitochondrial Protoporphyrinogen Oxidase by Gene Amplification in Photomixotrophic Tobacco Cells(Organic Chemistry)
• Intracellular targeting and distribution of protoporphyrinogen oxidase-II involved in chlorophyll and heme biosynthesis
• Purification and Properties of Protoporphyrinogen Oxidase from Spinach Chloroplasts
• Molecular characterization and subcellular localization of chloroplastic protoporphyrinogen oxidase in spinach
• Identification of a Toxic Mechanism of the Plasticizers, Phtahlic Acid Esters, which are Putative Endocrine Disrupters : Time-dependent Increase in Quinolinic Acid and Its Metabolites in Rats Fed di (2-ethylhexyl) phthalate(Food & Nutrition Science)
• Elucidation of the Toxic Mechanism of the Plasticizers, Phthalic Acid Esters, Putative Endocrine Disrupters : Effects of Dietary Di(2-ethylhexyl)phthalate on the Metabolism of Tryptophan to Niacin in Rats(Food & Nutrition Science)
• Marked Production of Ginsenosides Rd, F_2, Rg_3, and Compound K by Enzymatic Method
• Enzymatic Preparation of Ginsenosides Rg_2, Rh_1, and F_1
• Clinical Results of Carbon Ion Radiotherapy at NIRS
• Two Regions Responsible for the Actin Binding of p57, a Mammalian Coronin Family Actin-Binding Protein
• The Role of Protein Kinase C in the Transient Association of p57, a Coronin Family Actin-Binding Protein, with Phagosomes
• Effects of smoking on the lung accumulation of [^C]McN5652
• Enzymatic Preparation of Genuine Prosapogenin, 20 (S)-Ginsenoside Rh_1,from Ginsenosides Re and Rg_1
• Classification of Brassinosteroid-regulated Genes Based on Expression Profiles in bril and in Response to a Protein Kinase Inhibitor, Staurosporin
• Enzymatic Phosphatidylation of Thiamin, Pantothenic Acid, and Their Derivatives
• AtFLA11, a Fasciclin-Like Arabinogalactan-Protein, Specifically Localized in Screlenchyma Cells
• Effect of Lactational Exposure to Tributyltin Chloride on Innate Immunodefenses in the F1 Generation in Mice
• Preparation of Functional Single-Chain Antibodies against Bioactive Gibberellins by Utilizing Randomly Mutagenized Phage-Display Libraries
• Identification of Peptidyl Mimics of Bioactive Gibberellin Recognized by an Antibody
• Transglucosylation Activities of Multiple Forms of α-Glucosidase from Spinach(Biochemistry & Molecular Biology)
• SNF-4794: New Enzyme Inhibitors Produced by Chaetomella sp.
• Effect of Lactational Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin on the Susceptibility to Listeria Infection(Food & Nutrition Science)
• Expression of a Functional Single-chain Antibody against GA_ in Transgenic Tobacco
• Preparation and Application of Anti-idiotypic Antibody against Anti-gibberellin A_4 Antibody
• ENZYMIC FERULOYLATION OF ARABINOXYLAN OLIGOSACCHARIDE BY AN ENZYME EXTRACTED FROM SUSPENSION CULTURED RICE CELLS
• Structure of xylan from culms of bamboo grass (Sasa senanensis Rehd.)
• Binding kinetics of ^C-N-methyl piperidyl benzilate (^C-NMPB) in a rhesus monkey brain using the cerebellum as a reference region
• Effects of anesthesia upon ^F-FDG uptake in rhesus monkey brains
• Ionic interaction of [^C]-N, α-dimethylbenzylamine (DMBA) in rodent brain
• Different sensitivities to competitive inhibition of benzodiazepine receptor binding of ^C iomazenil and ^C-flumazenil in rhesus monkey brain
• MR Imaging of Brain Injury Induced by Carbon Ion Radiotherapy for Head and Neck Tumors
• Role of Atp7b Gene in Spontaneous and N-Diethylnitrosamine-induced Carcinogenesis in a New Congenic Strain, WKAH.C-Atp7b Rats
• Renal Targeting of Arginine-Vasopressin by Modification with Carbohydrates at the Tyrosine Side Chain
• Synthesis and Antidiuretic Activities of Novel Glycoconjugates of Arginine-Vasopressin
• 2-Arylmethyl-1,4-benzoquinones. II. Novel Inhibitors of Platelet Aggregation : Synthesis and Pharmacological Evaluation
• 2-Arylmethyl-1,4-benzoquinones. I. Novel Inhibitors of Platelet Aggregation : Synthesis and Pharmacological Evaluation
• Preparation and Pharmacological Evaluation of 1-(1,4-Benzoquinon-2-yl)-1,2,3,4-tetrahydronaphthalenes as Potent Cerebral Protective Agents
• Auxin Biosynthesis Inhibitors, Identified by a Genomics-Based Approach, Provide Insights into Auxin Biosynthesis
• Novel Malonamide Derivatives as α_vβ_3 Antagonists.Syntheses and Evaluation of 3-(3-Indolin-1-yl-3-oxopropanoyl)aminopropanoic Acids on Vitronectin Interaction with α_vβ_3
• 23aSH-9 High energy elastic scattering of ^6He+^C in a complete expansion of the Glauber amplitude
• Defense-Related Signaling by Interaction of Arabinogalactan Proteins and β-Glucosyl Yariv Reagent Inhibits Gibberellin Signaling in Barley Aleurone Cells
• Involvement of C-22-Hydroxylated Brassinosteroids in Auxin-Induced Lamina Joint Bending in Rice
• Brz220 Interacts with DWF4, a Cytochrome P450 Monooxygenase in Brassinosteroid Biosynthesis, and Exerts Biological Activity
• Arabidopsis Seedlings Over-Accumulated Indole-3-acetic Acid in Response to Aminooxyacetic Acid
• Feedback-Regulation of Strigolactone Biosynthetic Genes and Strigolactone-Regulated Genes in Arabidopsis
• STUDIES ON INFARCT SIZE AFTER THROMBOLYSIS IN ACUTE MYOCARDIAL INFARCTION. : INFARCT SIZE DETERMINED BY TTC METHOD : Myocardial Infarction : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
• 201 Central hypothyroidism resulting from pituitary suppression and peripheral thyrotoxicosis in a premature infant born to a mother with Hashimoto's disease presenting painless thyroiditis
• Dose Volume Analysis of Radiotherapy for Inoperable Patients with Stage I-II Endometrial Carcinoma
• 55.STUDY ON THE TRAINING AMOUNT OF SPORTSMEN (Report II) BOAT RACING AND SOCCER ATHLETES IN TRAINING CAMP.
• 1.THE PULSE RATE VARIATION IN BODY MOVEMENT

もっと見る 閉じる

スポンサーリンク