Galactosyldiacylglycerol, a Mammalian DNA Polymerase α-Specific Inhibitor from a Sea Alga, Petalonia bingbamiae
スポンサーリンク
概要
- 論文の詳細を見る
The glycolipid galactosyldiacylglycerol(GDG), containing C16:0 and C18:1 fatty acids, was isolated from the sea alga Petalonia bingbamiae as a potent inhibitor of the activities of mammalian DNA polymerase α(pol.α). GDG, however, had no effect on pol.α from a fish or a higher plant. The inhibition of pol.α by GDG was dose-dependent with an IC_<50> value of 54μM. The compound did not influence the activities of other replicative DNA polymerases such as mammalian pol.δ, or repair-related enzymes such as mammalian pol.β. GDG also did not influence the activities of prokaryotic DNA polymerases such as the Klenow fragment of DNA polymerase I, T4 DNA polymerase, Taq DNA polymerase, DNA polymerases from the higher plant, cauliflower, or DNA metabolic enzymes such as calf thymus terminal deoxynucleotidyl transferase, human immunodeficiency virus type 1 reverse transcriptase and deoxyribonuclease I. Kinetic analysis of the compound showed that pol.α was non-competitively inhibited with respect to both the DNA template and the nucleotide substrates. In this study, we demonstrated the structure-function relationships in the selective inhibition of pol.α by the glycolipid group.
- 公益社団法人日本薬学会の論文
- 2001-09-01
著者
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SUGAWARA Fumio
Department of Applied Biological Science, Tokyo University of Science
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YOSHIDA Hiromi
Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University
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MIZUSHINA Yoshiyuki
Laboratory of Food & Nutritional Sciences, Department of Nutritional Science, Kobe-Gakuin University
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SUGIYAMA Yuichi
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, The University of Tokyo
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SANEYOSHI MINEO
Department of Biological Sciences, Teikyo University of Sciences and Technology
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Yoshida S
Plant Science Center Riken Institute
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Yoshida S
Cancer Immunotherapy Center Nagoya Kyoritu Hospital
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Yoshida S
Laboratory Of Cancer Cell Biology Research Institute For Disease Mechanism And Control Nagoya Univer
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Yoshida Shonen
Laboratory Of Cancer Cell Biology Research Institute For Disease Mechanism And Control Nagoya Univer
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YAMAGUCHI Toyofumi
Department of Biological Sciences, The Nishi-Tokyo University
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KAMISUKI Shinji
Department of Applied Biological Science, Faculty of Science and Technology
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TAKEMURA Masaharu
Laboratory of Cancer Cell Biology, Research Institute for Disease Mechanism and Control, Nagoya Univ
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OHTA Keisuke
Department of Applied Biological Science, Science University of Tokyo
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Suzuki Y
Department Of Applied Biological Chemistry The University Of Tokyo
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Matsukage A
Department Of Chemical And Biological Sciences Faculty Of Science Japan Women's University
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Matsukage Akio
Department Of Chemical And Biological Sciences Japan Women's University
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HANASHIMA Shinya
Department of Applied Biological Science, Faculty of Science and Technology, Science University of T
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YAMAZAKI Takayuki
Department of Applied Biological Science, Faculty of Science and Technology, Science University of T
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SAKAGAUCHI Kengo
Department of Applied Biological Science, Faculty of Science and Technology, Science University of T
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TAKEMURA Masaharu
Life Science Research Center, Mie University
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Saneyoshi Mineo
Department Of Biological Sciences Teikyo University Of Sciences And Technology
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Saneyoshi Mineo
Department Of Biological Science Teikyo University Of Science And Technology
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Saneyoshi Mineo
Dept. Of Biol. Sci. Teikyo Univ. Sci. & Tech.
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Yoshida Shigeki
Inst. Applied Biochem. Tsukuba Univ.
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Suzuki Yoshihito
Department Of Applied Biological Chemistry The University Of Tokyo
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Takemura Masaharu
Life Science Research Center Mie University
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Sakagichi Ken-ichi
Institute For Protein Research Osaka University
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Yoshimura Hidetoshi
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Suzuki Y
Grad. Sch. Bioagric. Sci. Nagoya Univ.
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Yamaguchi T
Department Of Biological Science Teikyo University Of Science And Technology
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Yoshida S
Biological Research Laboratories Sankyo Co. Ltd.
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Sugawara F
Dep. Of Applied Biological Sci. Tokyo Univ. Of Sci.
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Sugawara Fumio
Dep. Of Applied Biological Sci. Tokyo Univ. Of Sci.
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Sugawara Fumio
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
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Ohta Keisuke
Department Of Anatomy & Histology Kurume University School Of Medicine
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Takemura M
Life Science Research Center Mie University
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Yoshida H
Lab. Of Food & Nutritional Sciences Dep. Of Nutritional Sci. Kobe-gakuin Univ.
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Kamisuki Shinji
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Kamisuki Shinji
Department Of Applied Biological Science Faculty Of Science And Technology
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Yoshimura H
Faculty Of Pharmaceutical Sciences Kyushu University(present):department Of Food And Nutrition Nakam
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Mizushima Y
Laboratory Of Food And Nutritional Sciences Department Of Nutritional Science Kobe-gakuin University
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Mizushina Y
Kobe‐gakuin Univ. Kobe Jpn
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Ohta Keisuke
Department Of Applied Biological Science Frontier Research Center For Genomic Drug Discovery Tokyo U
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Yamashita T
Laboratory Of Sapporo Cancer And Integrative Medicine Shinsapporo Keiaikai Hospital
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Sakaguchi Kengo
Department Of Applied Biological Science Tokyo University Of Science
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Sakaguchi Kengo
Department Of Applied Biological Science Faculty Of Science And Technology Tokyo University Of Scien
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Mizushina Yoshiyuki
Department Of Nutritional Science Kobe Gakuin University
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Yamazaki T
Protein Research Institute Osaka University
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Sugawara Fumio
Dep. Of Applied Biological Sci. Fac. Of Sci. And Technol. Tokyo Univ. Of Sci.
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Yamaguchi Toyofumi
Department Of Biological Sciences The Nishi-tokyo University
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Sugiyama Yuichi
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
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Hanashima Shinya
Department Of Applied Biological Science Science University Of Tokyo
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Shimada Hiroaki
Dep. Of Biological Sci. And Technol. Tokyo Univ. Of Sci.
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Takemura Masaharu
Laboratory Of Biology Education Graduate School Of Mathematics And Science Education Tokyo Universit
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Hanashima Shinya
Department of Applied Biological Science , Science University of Tokyo
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吉村 英敏
Department of Nutritional Science, Kobe Gakuin University
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Mizushina Yoshiyuki
Laboratofy of Food & Nutritional Sciences, Department al Nutritional Science, and High Technology Research Center, Kobe-Colmar University
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HANASHIMA Shinya
Department of Applied Biochemistry, Tokai University School of Engineering
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