Sulfoquinovosyldiacylglycerol, KM043,a New Potent Inhibitor of Eukaryotic DNA Polymerases and HIV-Reverse Transcriptase Type 1 from a Marine Red Alga, Gigartina tenella
スポンサーリンク
概要
- 論文の詳細を見る
A new sulfolipid, KM043,which belongs to the 6-sulfo-α-D-quinovopyranosyl-(1→3')-1', 2'-diacylglycerol (SQDG) class of compounds, has been isolated from a marine red alga, Gigartina tenella, as a potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1. Its structure was determined on the basis of spectroscopic and gas chromatographic analyses. The inhibition was dose-dependent, and complete (more than 90%)inhibition of DNA polymerase α (pol. α), DNA polymerase β (pol. β) and HIV-reverse transcriptase type 1 (HIV-RT) was observed at concentrations of 5,10,and 30 μM, respectively.
- 公益社団法人日本薬学会の論文
- 1998-04-15
著者
-
HIRATA Noriko
School of Pharmacy, Kinki University
-
SAKAGUCHI Kengo
Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Sci
-
SUGAWARA Fumio
Department of Applied Biological Science, Tokyo University of Science
-
Yoshida S
Plant Science Center Riken Institute
-
Hirata Noriko
3rd Section Of Research And Development Toyo Suisan Kaisha Ltd.
-
Hirata Noriko
Department Of Pharmaceutical Sciences Kinki University
-
Yoshida S
Cancer Immunotherapy Center Nagoya Kyoritu Hospital
-
Yoshida S
Laboratory Of Cancer Cell Biology Research Institute For Disease Mechanism And Control Nagoya Univer
-
Yoshida Shonen
Laboratory Of Cancer Cell Biology Research Institute For Disease Mechanism And Control Nagoya Univer
-
TAKEMURA Masaharu
Laboratory of Cancer Cell Biology, Research Institute for Disease Mechanism and Control, Nagoya Univ
-
OHTA Keisuke
Department of Applied Biological Science, Science University of Tokyo
-
MATSUKAGE Akio
Laboratory of Cell Biology, Aichi Cancer Center Research Institute
-
Matsukage A
Department Of Chemical And Biological Sciences Faculty Of Science Japan Women's University
-
Matsukage Akio
Department Of Chemical And Biological Sciences Japan Women's University
-
Matsukage Akio
Laboratory Of Cell Biology
-
Hirata N
3rd Section Of Research And Development Toyo Suisan Kaisha Ltd.
-
MIZUSHIMA Yoshiyuki
Department of Applied Biological Science, Faculty of Science and Technology, Science University of T
-
HIRATA Noriko
Development, Toyo Suisan Kaisha, Ltd.,
-
TAKEMURA Masaharu
Life Science Research Center, Mie University
-
Yoshida Shigeki
Inst. Applied Biochem. Tsukuba Univ.
-
Takemura Masaharu
Life Science Research Center Mie University
-
Sakagichi Ken-ichi
Institute For Protein Research Osaka University
-
Yoshida S
Biological Research Laboratories Sankyo Co. Ltd.
-
Sugawara F
Dep. Of Applied Biological Sci. Tokyo Univ. Of Sci.
-
Sugawara Fumio
Dep. Of Applied Biological Sci. Tokyo Univ. Of Sci.
-
Sugawara Fumio
Department Of Agricultural Chemistry Faculty Of Agriculture Tohoku University
-
Ohta Keisuke
Department Of Anatomy & Histology Kurume University School Of Medicine
-
Takemura M
Life Science Research Center Mie University
-
Mizushima Y
Laboratory Of Food And Nutritional Sciences Department Of Nutritional Science Kobe-gakuin University
-
Mizushina Y
Kobe‐gakuin Univ. Kobe Jpn
-
Ohta Keisuke
Department Of Applied Biological Science Frontier Research Center For Genomic Drug Discovery Tokyo U
-
Sakaguchi Kengo
Department Of Applied Biological Science Tokyo University Of Science
-
Sakaguchi Kengo
Department Of Applied Biological Science Faculty Of Science And Technology Tokyo University Of Scien
-
Sakaguchi Kengo
Department Of Applied Biological Science Faculty Of Science And Technology Science University Of Tok
-
Mizushina Yoshiyuki
Department Of Nutritional Science Kobe Gakuin University
-
Sugawara Fumio
Dep. Of Applied Biological Sci. Fac. Of Sci. And Technol. Tokyo Univ. Of Sci.
-
Mizushima Yoshiyuki
Department Of Applied Biological Science Science University Of Tokyo
-
Takemura Masaharu
Laboratory Of Biology Education Graduate School Of Mathematics And Science Education Tokyo Universit
-
Mizushina Yoshiyuki
Department of Applied Biological Science, Science University of Tokyo
関連論文
- Hydroxychavicol : a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle
- Histamine Release Inhibitory Activity of Piper nigrum Leaf(Pharmacognosy)
- Drosophila Damaged DNA Binding Protein 1 Contributes to Genome Stability in Somatic Cells
- Novel Terpenoids, Trichoderonic Acids A and B Isolated from Trichoderma virens, Are Selective Inhibitors of Family X DNA Polymerases
- Chemical Structure of Xylan in Cotton-seed Cake(Biological Chemistry)
- Preparation of Glucuronoxylo-oligosaccharides from an Acid Hydrolysate of Corn-hulls(Biological Chemistry)
- Action of Soymilk-clotting Enzyme from Bacillus sp. K-295G-7 on the Acidic Subunit of Soybean 11S Globulin(Biological Chemistry)
- Application of Soymilk-whey to Production of Beverage Containing α-D-Galactosyl Oligosaccharides(Food & Nutrition)
- Cloning and Sequence Analysis of cDNA for Irpex lacteus Aspartic Proteinase(Biological Chemistry)
- Substrate Specificity of Soymilk-clotting Enzymes I and II from Bacillus sp. K-295G-7 toward Peptide Substrates (Biological Chemistry)
- Purification and Characterization of Extracellular Poly(β-D-1, 4-mannuronide) Lyase from Dendryphiella salina IFO 32139
- Preparation of Dye-labeled Alginate for the Assay of Alginate Lyase
- Preparation of Two Series of Oligo-guluronic Acids from Sodium Alginate by Acid Hydrolysis and Enzymatic Degradation
- Structure of Rice-straw Arabinoglucuronoxylan and Specificity of Streptomyces Xylanase toward the Xylan(Biological Chemistry)
- Cross talk between auxin and other hormones in the early process of transdifferentiation into tracheary elements
- Effect of Diesel Exhaust on Development of Fetal Reproductive Function in ICR Female Mice
- Maternal Exposure to Diesel Exhaust Decreases Expression of Steroidogenic Factor-1 and Mullerian Inhibiting Substance in the Murine Fetus
- Effect of Dibromochloropropane (DBCP) on the Hormone Receptors of the Male Rat Reproductive System
- The Effects of Diesel Exhaust Particles (DEPs) on a Murine Testis (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
- Neoechinulin A impedes the progression of rotenone-induced cytotoxicity in PC12 cells
- Inhibitory Effects of Citrus hassaku Extract and Its Flavanone Glycosides on Melanogenesis(Pharmacognosy)
- Expression Pattern of the CsPK3 Auxin-Responsive Protein Kinase Gene
- Studies on Palauan Medicinal Herbs. I. Antidiabetic Effect of Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL
- Identification of a Peptide Mimic of Bioactive Gibberellins with Affinity to GA 2-Oxidase
- Sequential Regulation of Gibberellin, Brassinosteroid, and Jasmonic Acid Biosynthesis Occurs in Rice Coleoptiles to Control the Transcript Levels of Anti-Microbial Thionin Genes
- ISOLATION OF BRASSINOSTEROID DEFICIENCY-INSENSITIVE MUTANTS OF ARABIDOPSIS
- Analysis of the gene expression in response to brassinosteroids by using Gene Chip
- Crystallization and Preliminary X-ray Crystallographic Study of Streptomyces olivaceoviridis E-86 β-Xylanase
- Identification of Macrolide Antibiotic-binding Human_p8 Protein
- Identification of Antibiotic Clarithromycin Binding Peptide Displayed by T7 Phage Particles
- Neoechinulin A Impedes the Progression of Rotenone-Induced Cytotoxicity in PC12 Cells
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Umberiferae Plant Extracts and Their Coumarin Constituents(Pharmacognosy)
- Anti-proliferative effect of Ginseng Radix on human premyelocytic leukemia cells (HL-60)
- PCR Cloning and Expression of the F/10 Family Xylanase Gene from Streptomyces olivaceoviridis E-86
- Purification and Characterization of α-Glucuronidase from Snail Acetone Powder
- Chloroisonicotinamide Derivative Induces a Broad Range of Disease Resistance in Rice and Tobacco
- Thiadiazole carboxylic acid moiety of tiadinil, SV-03, induces systemic acquired resistance in tobacco without salicylic acid accumulation
- Synthesis of a Novel Class of Polyhydroxyalkanoates in Arabidopsis Peroxisomes, and Their Use in Monitoring Short-Chain-Length Intermediates of β-Oxidation
- Neoechinulin A Protects PC12 Cells against MPP^+-induced Cytotoxicity
- Structure-activity Relationships of Neoechinulin A Analogues with Cytoprotection against Peroxynitrite-induced PC12 Cell Death
- An Ergosterol Peroxide, a Natural Product That Selectively Enhances the Inhibitory Effect of Linoleic Acid on DNA Polymerase β
- Screening of Inhibitor of Eukaryotic DNA Polymerases Produced by Microorganisms
- Gum Arabic Enhances Intestinal Calcium Absorption in Rats
- Purification, Characterization, and cDNA Cloning of a Novel α-Galactosidase from Mortierella vinacea
- Purification and Some Properties of α-Galactosidase from Penicillium purpurogenum
- Galactosyldiacylglycerol, a Mammalian DNA Polymerase α-Specific Inhibitor from a Sea Alga, Petalonia bingbamiae
- The Cyanogenic Glucoside, Prunasin (D-Mandelonitrile-β-D-Glucoside), Is a Novel Inhibitor of DNA Polymerase β
- Action of a New Mammalian DNA Polymerase Inhibitor, Sulfoquinovosyldiacylglycerol
- Phytotoxins from the Septoria spp. Plant Pathogenic Fungus on Leafy Spurge
- Sulfoquinovosyldiacylglycerol, KM043,a New Potent Inhibitor of Eukaryotic DNA Polymerases and HIV-Reverse Transcriptase Type 1 from a Marine Red Alga, Gigartina tenella
- Phytoactive Eremophilanes Produced by the Weed Pathogen Drechslera gigantea
- (Z)-3-Hexenyl and trans-Linalool 3,7-oxide β-Primeverosides Isolated as Aroma Precursors from Leaves of a Green Tea Cultivar
- Selective Inhibition of DNA Polymerase ε by Phosphatidylinositol
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Kava (Piper methysticum) Rhizome Extract and Kavalactones(Pharmacognosy)
- Melanogenesis Stimulation in Murine B16 Melanoma Cells by Piper nigrum Leaf Extract and Its Lignan Constituents(Pharmacognosy)
- Purification and Characterization of Recombinant Mortierella vinacea α-Galactosidases I and II Expressed in Saccharomyces cerevisiae
- Direct Detection for β-Xylanase on Isoelectric Focusing Gels by Using 2,3,5-Triphenyltetrazolium Chloride
- Detection of α-L-Arabinofuranosidase Activity in Isoelectric Focused Gels using 6-Bromo-2-naphthyl-α-L-arabinofuranoside
- Resistance to Protoporphyrinogen Oxidase-inhibiting Compound S23142 from Overproduction of Mitochondrial Protoporphyrinogen Oxidase by Gene Amplification in Photomixotrophic Tobacco Cells(Organic Chemistry)
- Intracellular targeting and distribution of protoporphyrinogen oxidase-II involved in chlorophyll and heme biosynthesis
- Purification and Properties of Protoporphyrinogen Oxidase from Spinach Chloroplasts
- Molecular characterization and subcellular localization of chloroplastic protoporphyrinogen oxidase in spinach
- Anti-tumor Effect of Chemically Synthesized Sulfolipids Based on Sea Urchin's Natural Sulfonoquinovosylmonoacylglycerols
- Ovalbumin-Related Gene Y Protein Bears Carbohydrate Chains of the Ovomucoid Type
- Recognition of Native and/or Thermally Induced Denatured Forms of the Major Food Allergen, Ovomucoid, by Human IgE and Mouse Monoclonal IgG Antibodies
- Occurrence of the Major Food Allergen, Ovomucoid, in Human Breast Milk as an Immune Complex
- Testosterone 5α-Reductase Inhibitory Active Constituents of Piper nigrum Leaf(Pharmacognosy)
- Molecular Action Mode of Hippospongic Acid A, an Inhibitor of Gastrulation of Starfish Embryos
- ENZYMIC FERULOYLATION OF ARABINOXYLAN OLIGOSACCHARIDE BY AN ENZYME EXTRACTED FROM SUSPENSION CULTURED RICE CELLS
- Synthesis of Pseudodeflectusin and Ustusorane C: Structural Revision of Aspergione A and B
- Synthesis and Biological Activities of Neoechinulin A Derivatives : New Aspects of Structure-Activity Relationships for Neoechinulin A
- Downregulation of Tie2 gene by a novel antitumor sulfolipid, 3'-sulfoquinovosyl-1'-monoacylglycerol, targeting angiogenesis
- P-417 Affinity Purification of Proteins by the Specific Ligands Immobilized to Resins Used in Solid-phase Organic Synthesis
- P-112 Marine Natural Product, Sulfoquinovosylacylglycerol (SQAG), is a New Class of Anticancer Radiosensitizer and Strongly Binds to VEGF
- Structure of xylan from culms of bamboo grass (Sasa senanensis Rehd.)
- Effects of Unsaturated Uronic Acid Residues at Non-reducing End on Bond Cleavage Frequency of Poly(1, 4-α-L-guluronide) Lyase from Enterobacter cloacae M-1
- Substrate Specificities of α-Galactosidases from Yeasts
- Selective Inhibition of Mammalian DNA Polymerase α by Vitamin D_2 and D_3
- Chlorogenic acid is essential for root hair formation in the lettuce seedlings
- 座礁タンカ-からの流出重油に含まれる多環芳香族炭化水素のピレン資化性細菌による分解
- The Carboxyl Terminal Sequence of Nucleolar Protein B23.1 Is important in Its DNA Polymerase α-Stimulatory Activity
- Nucleolar Protein B23.1 Binds to Retinoblastoma Protein and Synergistically Stimulates DNA Polymerase α Activity^1
- A novel DNA topoisomerase inhibitor : dehydroebriconic acid, one of the lanostane-type triterpene acids from Poria cocos
- 1P594 Layer Silicates, Novel Nucleation-inducing Materials for Protein Crystallization(28. Macromolecular crystal growth,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- Three-Dimensional Structural Model Analysis of the Binding Site of an Inhibitor, Nervonic Acid, of Both DNA Polymerase β and HIV-1 Reverse Transcriptase
- Genomic Organization and Alternative Splicing of Human PACE4 (SPC4), Kexin-Like Processing Endoprotease
- Human Subtilisin-Like Proprotein Convertase, PACE4 (SPC4) Gene Expression Is Highly Regulated through E-Box Elements in HepG2 and GH4C1 Cells
- Protective Properties of Neoechinulin A against SIN-1-Induced Neuronal Cell Death
- Interaction between proliferating cell nuclear antigen (PCNA) and a DnaJ induced by DNA damage
- Chlorogenic Acid Facilitates Root Hair Formation in Lettuce Seedlings
- Effect on mutagenicity of degradation by Mycobacterium sp. of polycyclic aromatic hydrocarbons in heavy oil washed ashore
- Three-Dimensional Structural Model Analysis of the Binding Site of Lithocholic Acid, an Inhibitor of DNA Polymerase β and DNA Topoisomerase II^1
- Structure-Activity Relationship of a Novel Group of Mammalian DNA Polymerase Inhibitors, Synthetic Sulfoquinovosylacylglycerols
- A Novel Interaction between Calreticulin and Ubiquitin-Like Nuclear Protein in Rice
- Structure of Hardwood Xylan and Specificity of Streptomyces β-Xylanase toward the Xylan
- Isolation and characterization of a rice cDNA encoding B1-type cyclin-dependent kinase
- Novel Terpenoids, Trichoderonic Acids A and B Isolated from Trichoderma virens, Are Selective Inhibitors of Family X DNA Polymerases
- Synthesis of Pseudodeflectusin and Ustusorane C : Structural Revision of Aspergione A and B
- Hyper-Phosphorylated Retinoblastoma Protein Suppresses Telomere Elongation
- Studies on Palauan Medicinal Herbs. I. : Antidiabetic Effect of Ongael, Leaves of Phaleria cumingii (MEISN.) F. VILL.