Hyper-Phosphorylated Retinoblastoma Protein Suppresses Telomere Elongation
スポンサーリンク
概要
- 論文の詳細を見る
Immortalized cell lines maintain telomeres by the expression of telomerase or by a mechanism designated alternative lengthening of telomeres (ALT). Although DNA polymerase α (pol-α) is reported to be required for telomere maintenance, the critical role of pol-α in telomere maintenance has not been firmly determined. We examined the role of retinoblastoma protein (pRb) and pol-α in the regulation of telomere length, using telomere-fiber FISH. Telomere length varied dependent on the intracellular abundance of pol-α or pRb in HeLa cells. A proportion of hyper-phosphorylated pRb (ppRb) molecules localized to sites of telomeric DNA replication in HeLa cells. Pol-α might thus contribute to telomere maintenance, and might be regulated by ppRb.
- 社団法人 日本農芸化学会の論文
- 2008-02-23
著者
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Limsirichaikul Siripan
Division Of Molecular Carcinogenesis Center For Neurological Diseases And Cancer Nagoya University G
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Limsirichaikul Siripan
Department Of Biopharmacy Faculty Of Pharmacy Silpakorn University
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Suzuki Motoshi
Div. Of Molecular Carcinogenesis Center For Neural Disease And Cancer Nagoya Univ. Graduate School O
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Yoshida S
Plant Science Center Riken Institute
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Yamada Yoshiji
Department Of Gene Therapy Gifu International Institute Of Biotechnology And Institute Of Applied Bi
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Suzuki Motoshi
Nagoya Univ. Graduate School Of Medicine Nagoya Jpn
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Suzuki Motoshi
Division Of Molecular Carcinogenesis Center For Neurological Diseases And Cancer Nagoya University G
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Yoshida Shigeki
Inst. Applied Biochem. Tsukuba Univ.
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OKUMURA Katsuzumi
Department of Bioscience, Faculty of Bioresources, Mie University
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Yoshida Shonen
Cancer Immunotherapy Center Nagoya Kyoritu Hospital
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Takemura Masaharu
Department Of Biology Faculty Of Science Tokyo University Of Science (rikadai)
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Sugimura Kazuto
Department Of Life Sciences Faculty Of Bioresources Mie University
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Okumura Katsuzumi
Department Of Life Sciences Faculty Of Bioresources Mie University
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