Effect of Diesel Exhaust on Development of Fetal Reproductive Function in ICR Female Mice

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概要

• 論文の詳細を見る

• Diesel exhaust (DE) is a serious air pollution problem in big cities. Most suspended particulate matter (SPM) less than 2.5 μm in diameter consists of diesel exhaust particles (DEPs), which are reported to cause pulmonary carcinogenesis, allergic rhinitis, and bronchial asthma-like diseases. It has been recently reported that DE also affects the circulatory and reproductive systems. Yoshida et al. reported that mRNA expression of steroidogenic factor-1 (Ad4BP/SF-1) and of Mullerian inhibitory substance (MIS), which are essential for male gonadal differentiation, decreased significantly in male fetuses when maternal mice were exposed to DE at levels of 0.1 or 3.0 mg DEP/m^3 for 8 hr per day between 2 and 13 days postcoitum (dpc). In this study, maternal mice were exposed to DE 0.1 mg DEP/m^3 for 8 hr per day between 2 and 13 dpc. Expression levels of Ad4BP/SF-1 and MIS mRNA in female fetuses were not decreased. However, expression levels of bone morphogenetic protein-15, reported to be related to development of the oocyte, were significantly decreased in comparison with that in the control group. Our data suggest that female fetuses of pregnant mice exposed to DE in utero are less sensitive to the expression levels of mRNAs for Ad4BP/SF-1 and MIS compared with males and that DE may affect development of the oocyte in the female fetus.

• 社団法人日本薬学会の論文
• 2004-04-01

著者

• Takeda Ken

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Takeda Ken

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Tsukue Naomi

  Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Yoshida Seiichi

  Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Sugawara Isamu

  Core Research for Evolutional Science and Technology, Japan Science and Technology Agency

• Yoshida S

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science:core

• Yoshida Seiichi

  東京理科大学 薬学部衛生化学

• Sugawara I

  The Res. Inst. Of Tuberculosis Japan Anti-tuberculosis Assoc.

• Sugawara I

  Department Of Pathology Saitama Medical Center Saitama Medical School

• Sugawara Isamu

  The Research Institute Of Tuberculosis Japan Anti-tuberculosis Association

• Sugawara Isamu

  東京大学医科学研究所

• Sugawara Isamu

  Department Of Pathology Institute Of Medical Science University Of Tokyo

• Tsukue Naomi

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science:core

• Tsukue Naomi

  東京理科大学 薬学部衛生化学

• Yoshida S

  Laboratory Of Cancer Cell Biology Research Institute For Disease Mechanism And Control Nagoya Univer

• Yamaguchi S

  Material Science Research Center Shiseido Co. Ltd.

• Yamaguchi Shoko

  Material Science Research Center Shiseido Co. Ltd.

• Yoshida Seiichi

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• Takeda K

  Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Yoshida S

  Sci. Univ. Tokyo Tokyo Jpn

• Takeda Ken

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science

• Yoshida Seiichi

  Deparhllent Of Biology Tokyo Metropolitan University

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