Maternal Exposure to Diesel Exhaust Leads to Pathological Similarity to Autism in Newborns

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概要

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• We have already demonstrated many diesel exhaust particles (DEPs) and some damages in brain tissues (cerebral cortex and hippocampus) of newborn mice whose mothers inhaled DE during pregnancy, and these damages have the possibilities to lead to some disorders of nervous system. In this study, we examined pathological effects on newborn brain by DE-exposure to pregnant mice, especially focused on autism. ICR pregnant mice were exposed to DE and some were exposed to clean air as a comparative control. Brain tissues (cerebellum) were obtained from the mice (housed in a clean air) born from DE-exposure and control pregnant mice, and examined with light and electron microscope. To detect apoptosis, the immunohistochemical staining for caspase-3 was performed, especially; the numbers of positive Purkinje cell in cerebellum were compared between DE-exposure and control. In DE-exposure group, numerous caspase-3 positive cells were diffusely observed and the number of positive Purkinje cells was significant large than in control. Electron microscopically, specific features of apoptosis were found in Purkinje cells in the DE-exposure group. These findings indicate that DE-exposure to pregnant mice has a severe impact on fetal brain development and, especially, numerous apoptotic Purkinje cells cause the innate deficiency of them and would involve the pathogenic backing of autism. Our results would give a grave warning that the maternal inhalation of DE is hazardous to fetuses' health and it is possible that these fetal damages carries a great risk of various disorders of nervous system afterward, such as autism.

• 社団法人日本薬学会の論文
• 2006-08-01

著者

• Sugamata Masao

  Department Of Pathology Tochigi Institute Of Clinical Pathology

• Sugamata Masao

  Dppartment Of Pathology Tochigi Institute Of Clinical Pathology

• Takeda Ken

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Takeda Ken

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• IHARA Tomomi

  Department of Pathology, Tochigi Institute of Clinical Pathology

• Sugamata Miho

  Department of Pathology, Omori Hospital, Toho University School of Medicine

• Sugamata M

  Department Of Pathology Tochigi Institute Of Clinical Pathology

• Sugamata M

  Tochigi Inst. Clinical Pathology Tochigi Jpn

• Ihara Tomomi

  Tochigi Inst. Clinical Pathology Tochigi Jpn

• Ihara T

  Toho Univ. Tokyo Jpn

• Sagai Masaru

  Research Team For Health Effects Of Air Pollutants National Institute For Environmental Studies (nie

• Sugamata Masao

  Department Of Pathology Institute Of Tochigi Clinical Pathology Japan

• Takeda K

  Division Of Instrumental Analysis Institute Of Resource Development And Analysis Kumamoto University

• Takeda K

  Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Ihara Tomomi

  Department Of Pathology Institute Of Tochigi Clinical Pathology Japan

• Sugamata Miho

  Department Of Pathology Omori Hospital Toho University School Of Medicine

• Takeda Ken

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science

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