Okadaic Acid Remarkably Suppresses Testosterone Production in Murine Leydig Cells

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概要

• 論文の詳細を見る

• Okadaic acid, a tumor promoter derived from a black sponge, dose-dependently suppressed human chorionic gonadotropin (hCG)-stimulated testosterone production in primary cultured mouse Leydig cells. Okadaic acid at 10 HM caused a 70% reduction in testosterone production, and this inhibition was not due to cell damage. Okadaic acid did not affect basal testosterone production. Our results suggest that okadaic acid may inhibit the hCG-stimulated signaling pathway. We found that okadaic acid suppressed the expression of mRNA for two steroidogenic enzymes, cytochrome P450 cholesterol side-chain cleavage (P450scc) and 3β-hydroxysteroid dehydrogenase (3β-HSD), which catalyze cholesterol conversion to testosterone. It is interesting to analyze the mechanisms by which okadaic acid, which inhibits protein phosphatase 1 and 2A, suppressed steroidogenesis.

• 社団法人日本薬学会の論文
• 2001-02-01

著者

• Nagao Kenji

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• Takeda Ken

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Takeda Ken

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Tabata Masako

  Department of Hygiene Chemistry, Faculty of Pharmaceutical Science, Tokyo University of Science

• Asada Shin

  Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo

• Koga Motokazu

  Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo

• Tabata Masako

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science

• Tabata Masako

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 田畑 勝弘

  Biostructural Science Department Of Hard Tissue Engineering Division Of Bio-matrix Graduate School O

• Tabata M

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science

• 田畑 勝弘

  富山工業高等専門学校

• Asada Shin

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• Takeda K

  Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Takeda Ken

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science

• Koga M

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• Nagao Kenji

  Department Of Agricultural Chemistry The University Of Tokyo

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