Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Testosterone Production in Isolated Murine Testicular Cells
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概要
- 論文の詳細を見る
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an endocrine disruptor that is known to have widespread effects on the reproductive system. We examined the effects of TCDD on testosterone production of primary cultured murine testicular cells. The cells, derived from the testes of ICR mice at age 65 days, were exposed to 10^<-2>-10^4 pM TCDD for 3,24, or 48 hr and treated with human chorionic gonadotropin for 6 hr to induce production of testosterone. At these concentrations of TCDD, the viability of testicular cells was not affected. No significant time- or TCDD concentration-dependent effects were observed on the secretion of testosterone. The data suggest that TCDD does not have a direct influence on testosterone production in the ICR mouse.
- 公益社団法人日本薬学会の論文
- 2002-06-01
著者
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UCHIDA Tatsuya
Department of Chemistry, Graduate School of Science, Tohoku University
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Takeda Ken
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Yoshida Seiichi
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Uchida Tatsuya
Department Of Chemistry Faculty Of Science Graduate School Kyushu University
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Uchida Tatsuya
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Yoshida Seiichi
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Inui Yosuke
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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Inui Yosuke
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Takeda Ken
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science
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Yoshida Seiichi
Deparhllent Of Biology Tokyo Metropolitan University
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Takeda Ken
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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