Immunological Study of Interleukin-2 in the Patients with Malignant Brain Tumors
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概要
- 論文の詳細を見る
The authors studied the capacity of peripheral blood lymphocytes from patients with malignant brain tumors to produce, and to respond to, interleukin-2 (IL-2). The role of IL-2 in generation of T cells cytotoxic to tumor cells was also studied. Lymphocytes from the patients with malignant brain tumors produced less IL-2 than did those of normal controls. However, phytohemagglutinin-activated peripheral blood lymphocytes from normal controls and the patients responded equally well to IL-2. This indicates that IL-2 receptors are abundant in the patients' lymphocytes, although IL-2 production may be depressed. Furthermore, after incubation with IL-2, lymphocytes from patients with malignant glioma exhibited higher natural killer activity and strong cytotoxicity to glioma cells. Its tumor cell cytotoxicity makes IL-2 a likely candidate for use in adoptive immunotherapy.
- 日本脳神経外科学会の論文
- 1988-07-15
著者
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Yoshida Seiichi
Department Of Neurosurgery Brain Research Institute Niigata University
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Yoshida Seiichi
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Tanaka Ryuichi
Department Of Neurosurgery Brain Research Institute Niigata University
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Takai Nobuyuki
Department Of Neurological Surgery Niigata Rosai Hospital
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Takai Nobuyuki
Department Of Neurosurgery Brain Research Institute Niigata University
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Yoshida Seiichi
Deparhllent Of Biology Tokyo Metropolitan University
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Tanaka Ryuichi
Department Of Liberal Arts Faculty Of Science And Technology Tokyo University Of Science
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