Tumor-Promoting Activity of Phthalate Esters Estimated by in Vitro Transformation Using Bhas Cells
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概要
- 論文の詳細を見る
The tumor-promoting activity of four phthalate diesters and three monoesters were tested in vitro in a screening assay using a transformed and non transformed BALB/c3T3 cell mixture and in a transformation assay using Bhas cells (v-Ha-ras-transfected BALB/3T3 cells). Di-2-ethylhexyl phthalate (DEHP), di-n-butyl phthalate (DBP), and their monoesters increased cell proliferation in the screening assay. Mono-n-butyl phthalate (MBuP) and mono-2-ethylhexyl phthalate (MEHP) promoted Bhas cell transformation, whereas the activities of DBP and DEHP were weak. The activity of MEHP was about 1/500 that of 12-O-tetra-decanoyl-phorbol-13-acetate. MBuP and MEHP therefore showed tumor-promoting activity, whereas all the other phthalate esters tested, including di-iso-nonyl phthalate, had little or no such activity. In addition, MBuP and MEHP were formed by hydrolysis in Bhas cells exposed to DBP and DEHP for 4 days. We postulate that MEHP plays a role in the slight ability of DEHP to promote cell proliferation.
- 公益社団法人日本薬学会の論文
- 2003-02-01
著者
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Takeda Ken
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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TAKEDA Ken
Faculty of Pharmaceutical Sciences, Science University of Tokyo (SUT)
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Onodera Sukeo
Faculty of Pharmaceutical Sciences, Tokyo University of Science
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NIINO Tatsuhiro
Tokyo Kenbikyo-in Foundation, Center of Food & Environmental Sciences
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ISHIBASHI Tohru
Tokyo Kenbikyo-in Foundation, Center of Food & Environmental Sciences
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FUSHIWAKI Yuichi
Kanagawa Prefectural Institute of Public Health
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Takeda K
Division Of Instrumental Analysis Institute Of Resource Development And Analysis Kumamoto University
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Onodera S
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Onodera Sukeo
Faculty Of Pharmaceutical Science Science University Of Tokyo
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Onodera Sukeo
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Niino Tatsuhiro
Mitsubishi Chemical Safety Institute Ltd.
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Takeda Ken
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Fushiwaki Y
Kanagawa Prefectural Institute Of Public Health
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Ishibashi Tohru
Tokyo Kenbikyo-in Foundation Center Of Food & Environmental Sciences
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Niino Tatsuhiro
Tokyo Kenbikyo-in Foundation Center Of Food & Environmental Sciences
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Takeda Ken
Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Takeda Ken
The Center For Environmental Health Science For The Next Generation Research Institute Far Science And Technology Tokyo University Of Science
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Ishibashi Tohru
Tokyo Kenbikyo-in Foundation, Center of Food & Environmental Sciences
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