Effect of Dibromochloropropane (DBCP) on the Hormone Receptors of the Male Rat Reproductive System

スポンサーリンク

概要

• 論文の詳細を見る

• The effects of dibromochloropropane (DBCP), a pesticide, on the male rat reproductive system were examined at morphological and hormonal expression levels. Changes of Leydig cells and seminiferous tubules were examined in rats treated with one subcutaneous (s.c.) injection of DBCP at doses of 10, 50, 75 and 100mg/kg of body weight.The Leydig cells degenerated and decreased in number in those rats with an s.c.injection of DBCP at a dose of 50 mg/kg of body weight.However, these morphological changes were not significant in those rats that were treated with four separate s.c.injections of DBCP at 10 mg/kg of body weight.The expression of luteinizing hormone receptor mRNA, which is specifically expressed in Leydig cells, was decreased significantly in the DBCP-treated rats as compared with the normal-control rats.The expression of follicle-stimulating hormone receptor mRNA was decreased to a mild degree in DBCP-treated rats.At a dose of 75 mg/kg of body weight, seminiferous tubules as well as Leydig cells were severely damaged morphologically and at hormonal receptor expression levels.Multinucleated giant cells appeared at a dose of 45 mg/kg of body weight. All the rats died at a dose of 100 mg/kg of body weight. Our data indicate that DBCP had a cytotoxic effect on the male rat reproductive system in a dose-dependent manner.

• 社団法人日本農芸化学会の論文
• 1998-03-23

著者

• Takeda Ken

  Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Takeda Ken

  Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Sugawara Isamu

  Department of Molecular Pathology The Research Institute of Tuberculosis

• YOSHIDA Seiichi

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• YAMADA Hiroyuki

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• Yoshida S

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science:core

• Yoshida Seiichi

  東京理科大学 薬学部衛生化学

• Sugawara I

  The Res. Inst. Of Tuberculosis Japan Anti-tuberculosis Assoc.

• Sugawara I

  Department Of Pathology Saitama Medical Center Saitama Medical School

• Sugawara Isamu

  The Research Institute Of Tuberculosis Japan Anti-tuberculosis Association

• Sugawara Isamu

  東京大学医科学研究所

• Sugawara Isamu

  Department Of Pathology Institute Of Medical Science University Of Tokyo

• Yoshida S

  Laboratory Of Cancer Cell Biology Research Institute For Disease Mechanism And Control Nagoya Univer

• Sugawara Isamu

  Department Of Molecular Pathology Reserch Institute Of Tuberculslosis

• Yamaguchi S

  Material Science Research Center Shiseido Co. Ltd.

• Yamaguchi Shoko

  Material Science Research Center Shiseido Co. Ltd.

• Takeda K

  Faculty Of Pharmaceutical Sciences Tokyo University Of Science

• Yoshida S

  Sci. Univ. Tokyo Tokyo Jpn

• Takeda Ken

  Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science

• Yamada Hiroyuki

  Faculty of Engineering, Ehime University

関連論文

• Novel insights into pathology of endometriosis from a disease model induced by autotransplantation of endometrium
• Early Development Origins of Adult Disease Caused by Malnutrition and Environmental Chemical Substances
• Identification of reaction products of 9-hydroxy-10-oxo-12(Z), 15(Z)-octadecadienoic acid (KODA) and norepinephrine that strongly induce flowering in Lemna
• Purification and Characterization of Extracellular Poly(β-D-1, 4-mannuronide) Lyase from Dendryphiella salina IFO 32139
• Preparation of Dye-labeled Alginate for the Assay of Alginate Lyase
• Preparation of Two Series of Oligo-guluronic Acids from Sodium Alginate by Acid Hydrolysis and Enzymatic Degradation
• Cross talk between auxin and other hormones in the early process of transdifferentiation into tracheary elements
• Nanoparticles Transferred from Pregnant Mice to Their Offspring Can Damage the Genital and Cranial Nerve Systems
• Diesel Exhaust Exposure Enhances the Persistence of Endometriosis Model in Rats
• Maternal Exposure to Diesel Exhaust Leads to Pathological Similarity to Autism in Newborns
• Maternal Diesel Exhaust Exposure Damages Newborn Murine Brains
• Effect of Diesel Exhaust on Development of Fetal Reproductive Function in ICR Female Mice
• Maternal Exposure to Diesel Exhaust Decreases Expression of Steroidogenic Factor-1 and Mullerian Inhibiting Substance in the Murine Fetus
• Okadaic Acid Remarkably Suppresses Testosterone Production in Murine Leydig Cells
• Effect of Dibromochloropropane (DBCP) on the Hormone Receptors of the Male Rat Reproductive System
• Effects of Diesel Exhaust Inhalation on Asthma Model of Mice (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
• The Effects of Diesel Exhaust Particles (DEPs) on a Murine Testis (Proceedings of the 22nd Symposium on Toxicology and Environmental Health)
• Structural Changes and Apoptotic Cell Death by T-2 Toxin (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
• Expression Pattern of the CsPK3 Auxin-Responsive Protein Kinase Gene
• Identification of a Peptide Mimic of Bioactive Gibberellins with Affinity to GA 2-Oxidase
• Sequential Regulation of Gibberellin, Brassinosteroid, and Jasmonic Acid Biosynthesis Occurs in Rice Coleoptiles to Control the Transcript Levels of Anti-Microbial Thionin Genes
• ISOLATION OF BRASSINOSTEROID DEFICIENCY-INSENSITIVE MUTANTS OF ARABIDOPSIS
• Analysis of the gene expression in response to brassinosteroids by using Gene Chip
• Light regulation of brassinosteroid-biosynthetic genes in Arabidopsis thaliana
• Cloning of Brassinosteroid-6-Oxidase from Arabidopsis thaliana
• Regulatory Mechanism of Photomorphogenesis by Pytohormones -An Analysis with Brassinosteroid-Biosynthesis-Specific Inhibitor, Brassinazole (Brz)
• EFFECTS OF SPECIFIC BRASSIONSTEROID (BR) BIOSYNTHESIS INHIBITOR (BRASSINAZOLE : Brz) ON PLANTS
• BRASSINOSTEROID BIOSYNTHESIS INHIBITOR : STRUCTURE, ACTIVITY AND TARGET SITES
• Crystallization and Preliminary X-ray Crystallographic Study of Streptomyces olivaceoviridis E-86 β-Xylanase
• Cortical Laminar Necrosis in a Patient with Moyamoya Disease Associated with Down Syndrome: MR Imaging Findings
• PCR Cloning and Expression of the F/10 Family Xylanase Gene from Streptomyces olivaceoviridis E-86
• Purification and Characterization of α-Glucuronidase from Snail Acetone Powder
• Identification of Three Clones Which Commonly Interact with the Kinase Domains of Highly Homologous Two Receptor-Like Kinases, RLK902 and RKL1
• Molecular Characterization of Two Highly Homologous Receptor-like Kinase Genes, RLK902 and RKL1, in Arabidopsis thaliana
• Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice
• Newly Designed Primer Sets Available for Evaluating Various Cytokines and iNOS mRNA Expression in Guinea Pig Lung Tissues by RT-PCR
• Mycobacterial Infection in MyD88-Deficient Mice
• Mycobacterial Infection in TLR2 and TLR6 Knockout Mice
• Interferon Regulatory Factor 1 in Mycobacterila Infection
• Role of Interleukin (IL)-1 Type 1 Receptor in Mycobacterial Infection
• Results of Radiation Therapy for Uterine Cervical Cancer Using High Dose Rate Remote After Loading System
• Immunohistochemical Detection of Human Cellular Yes Gene (C-Yes-1) Messenger Rna by A Non-Radioactive Synthesized Oligodeoxynucleotide Probe
• IN SITU LOCALIZATION OF c-MYC mRNA IN HL-60 CELLS USING NON-RADIOACTIVE SYNTHETIC OLIGODEOXYNUCLEOTIDE PROBES
• In situ localization of specific mRNA using T-T dimerized single-stranded DNA probes.
• Myxoinflammatory fibroblastic sarcoma
• Soybean isoflavones preserve bone mass in hindlimb-unloaded mice
• Anti-proliferative Effect of Toremifene and Tamoxifen on Estrogen Receptor-lacking Anaplastic Thyroid Carcinoma Cell Lines
• Cytokeratin expression in normal human thymus at different ages
• A Case of Encapsulated Noninvasive Thymoma (Stage I) with Myasthenia Gravis Showing Metastasis After a 2-Year Dormancy
• W1-3 Effect of Pollutants on Allergic Airway Responses : Studies with Diesel Exhaust Particles(DEP)in vitro and in vivo.
• In situ hybridization in infectious diseases
• High-level Expression of P-glycoprotein and 85 kD Protein as Assessed by Flow Cytometry and Immunocytochemistry in Leukemias and Malignant Lymphomas
• Anticoagulant Activity of Sulfated Schizophyllan
• Preparation and Characterization of Murine Anti-Schizophyllan Monoclonal Antibody, SPG1-HS
• Construction of X-ray Dark-Field Imaging with a View Size of 80mm Square and First Visualization of Human Articular Cartilage of Femoral Head under a Nearly Clinical Condition
• Diesel exhaust (DE) aggravates pathology of delayed-type hypersensitivity (DTH) Induced by methyl-bovine serum albumin (mBSA) in mice
• Predictive Factors for Acute Esophageal Toxicity in Thoracic Radiotherapy
• Epitope Analysis Using Anti-Oligosaccharide (G4) Monoclonal Antibody
• Preparation of Polyclonal Antibodies to an Anti-tumor (1→3)-β-D-Glucan, Schizophyllan(Biological Chemistry)
• Biological Activity of Sulfated Schizophyllan
• BCG Vaccination Enhances Resistance to M. Tuberculosis Infection in Guinea Pigs Fed a Low Casein Diet
• Pulmonary Tuberculosis in Spontaneously Diabetic Goto Kakizaki Rats
• STAT1 Knockout Mice are Highly Susceptible to Pulmonary Mycobacterial Infection
• IL-4 Is Required for Defense against Mycobacterial Infection
• Comparison of Conjugative Activity, Conversion of Bisphenol A to Bisphenol A Glucuronide, in Fetal and Mature Male Rat
• Passage of Bisphenol A into the Fetus of the Pregnant Rat
• TRICHOTHECENES PRODUCED BY Fusarium kyushuiense sp.nov.(=F.sp.Fn 2B)AND THEIR COMPARATIVE CYTOTOXICITY
• Stress-Induced Factor Involved in Flower Formation of Lemna is an α-Ketol Derivative of Linolenic Acid
• Endogenous α-Ketol Linolenic Acid Levels in Short Day-Induced Cotyledons are Closely Related to Flower Induction in Pharbitis nil
• Identification of a Component that Induces Flowering of Lemna among the Reaction Products of α-Ketol Linolenic Acid (FIF) and Norepinephrine
• CHEMICAL STRUCTURE OF THE MAJOR COMPONENTS OF REACTANTS BETWEEN FIF AND NOREPINEPHRINE WHICH STRONGLY INDUCE FLOWER FORMATION OF LEMNA
• INDOLEBUTYROLACTONE APPEARED AT EARLY STAGE OF IBA-INDUCED ROOTING OF SAIKO
• THE STRUCTURE OF STRESS-INDUCED FLOWER-INDUCING FACTOR (FACTOR C) IN Lemna
• Stress Enhances Indole-3-butyric Acid-induced Rooting in Bupleurum falcatum L. (Saiko) Root Culture
• Formation of Defects in Near-Surface Region over Li or Mn-Doped MgO Studied by Mg K-Edge XANES
• Analysis of Responsive Genes of Murine Leydig Cells by 2,3,7,8-Tetrachlorodibenzo-p-dioxin
• Analysis of Gene Expression Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mouse Leydig Cells (Proceedings of the 23rd Symposium on Toxicology and Environmental Health)
• Tumor-Promoting Activity of Phthalate Esters Estimated by in Vitro Transformation Using Bhas Cells
• Characterization of Human Salivary Esterase in Enzymatic Hydrolysis of Phthalate Esters
• Detection of a Helicobacter pylori Gene Marker in Gastric Biopsy Samples by Non-radioactive in situ Hybridization
• Secondary Infections of AIDS Autopsy Cases in Japan with Special Emphasis on Mycobacterium Avium-Intracellulare Complex Infection
• ^F-fluorodeoxyglucose positron emission tomography immediately after chemoradiotherapy predicts prognosis in patients with locoregional postoperative recurrent esophageal cancer
• Proteome Analysis of the Effects of 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin on Murine Testicular Leydig and Sertoli Cells
• Establishment of A Guinea Pig Model of Latent Tuberculosis with GFP-introduced Mycobacterium Tuberculosis
• Aggravating effect of natural sand dust on male reproductive function in mice
• Transient role of CD4^+CD25^+ regulatory T cells in mycobacterial infection in mice
• A Model for Detecting Cost-Prone Classes Based on Mahalanobis-Taguchi Method(Knowledge-Based Software Engineering)
• A Graph-Based Class Structural Complexity Metric and Its Evaluation(Special Issue on Knowledge-Based Software Engineering)
• Postoperative deep infection in tumor endoprosthesis reconstruction around the knee
• Effect of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on Testosterone Production in Isolated Murine Testicular Cells
• 5-Aza-2-deoxycytidine reactivates the CDH1 gene without influencing methylation of the entire CpG island or histone modification in a human cancer cell line
• Predicting the Severity of Acute Urinary Toxicity after Brachytherapy with Iodine-125 for Localized Prostate Cancer
• Transient accumulation of α-ketol linolenic acid (KODA) in immature flower buds of some ornamental plants
• Pathological study for the effects of in utero and postnatal exposure to diesel exhaust on a rat endometriosis model
• Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney of offspring
• Effects of Fetal Exposure to Urban Particulate Matter on the Immune System of Male Mouse Offspring
• 2-B-05 Comparison of spontaneous and forced running on the hypothalamic gene expression using microarray and Medical Subject Headings analysis(The Proceedings of the 19th Annual Meetings of Japan Society of Exercise and Sports Physiology August 25・26, (To
• A novel root inducer, 4-(3-indolyl)-4-butanolide (IBL), is formed at an early stage in Bupleurum falcatum L. root cultures containing indole-3-butyric acid (IBA)
• A Constructing Method of Functional Model by Integrated Learning from Examples of Software Modification
• Prenatal exposure to zinc oxide particles alters monoaminergic neurotransmitter levels in the brain of mouse offspring

もっと見る 閉じる

スポンサーリンク