Maternal Exposure to Diesel Exhaust Decreases Expression of Steroidogenic Factor-1 and Mullerian Inhibiting Substance in the Murine Fetus
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概要
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We investigated the effect of exposure of pregnant mice to diesel exhaust on male gonad development at the level of mRNA expression. Expression of mRNAs for steroidogenic factor-1 (Ad4BP/SF-1) and Mullerian inhibitory substance (MIS), which are essential for male gonadal differentiation, decreased significantly in male fetuses when maternal mice were exposed to diesel exhaust at levels of 0.1 mg and 3.0 mg diesel exhaust particles (DEP)/m^3 for 8 hr per day between days 2 and 13 post coitum. Expression levels of mRNAs for steroidogenic cytochrome P450 genes regulated by Ad4BP/SF-1, especially 3β-hydroxysteroid dehydrogenase (3β-HSD) and aromatase, were also decreased by exposure to diesel exhaust. There were no significant differences in levels of estrogen receptor (ER) or androgen receptor (AR) mRNAs between control and exposed mice. The data indicate that exposure of pregnant mice to diesel exhaust affects the expression of genes essential in the early stages of embryonic development.
- 社団法人日本薬学会の論文
- 2002-08-01
著者
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Takeda Ken
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Takeda Ken
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Yoshida Seiichi
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Yoshida Miki
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Sugawara Isamu
Department of Molecular Pathology The Research Institute of Tuberculosis
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Yoshida S
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science:core
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Yoshida Seiichi
東京理科大学 薬学部衛生化学
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Sugawara I
The Res. Inst. Of Tuberculosis Japan Anti-tuberculosis Assoc.
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Sugawara I
Department Of Pathology Saitama Medical Center Saitama Medical School
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Sugawara Isamu
The Research Institute Of Tuberculosis Japan Anti-tuberculosis Association
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Sugawara Isamu
東京大学医科学研究所
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Sugawara Isamu
Department Of Pathology Institute Of Medical Science University Of Tokyo
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Yoshida S
Laboratory Of Cancer Cell Biology Research Institute For Disease Mechanism And Control Nagoya Univer
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Yoshida M
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Sugawara Isamu
Department Of Molecular Pathology Reserch Institute Of Tuberculslosis
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Yamaguchi S
Material Science Research Center Shiseido Co. Ltd.
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Yamaguchi Shoko
Material Science Research Center Shiseido Co. Ltd.
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Yoshida Seiichi
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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Takeda K
Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Yoshida S
Sci. Univ. Tokyo Tokyo Jpn
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Yasuda Mineo
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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Takeda Ken
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Science Tokyo University Of Science
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Yoshida Seiichi
Deparhllent Of Biology Tokyo Metropolitan University
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竹田 靖史
鹿児島大学
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吉元 寧
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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松田 正成
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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花城 勲
Department of Molecular Pathology The Research Institute of Tuberculosis
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竹之内 忠廣
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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