Interconversion between Fenthion and Fenthion Sulfoxide in Goldfish, Carassius auratus
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概要
- 論文の詳細を見る
The in vitro metabolism of fenthion , an insecticide, was examined in fish, focusing on the interconversion between fenthion and its sulfoxide (fenthion sulfoxide). When fenthion was incubated with hepatopancreas microsomes of goldfish, Carassius auratus, in the presence of NADPH, the oxidized metabolite, fenthion sulfoxide was formed, but not fenthion sulfone. The oxidase activity was inhibited by SKF 525-A, and partly by α-naphthylthiourea. In contrast, fenthion sulfoxide was reduced back to fenthion by the hepatopancreas cytosol of goldfish in the presence of 2-hydroxypyrimidine, an electron donor for aldehyde oxidase. The activity was markedly inhibited by menadione, an inhibitor for aldehyde oxidase. The interconversion appears to be mediated mainly by the cytochrome P450 system and aldehyde oxidase.
- 社団法人日本薬学会の論文
- 1999-10-31
著者
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KITAMURA Shigeyuki
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Kitamura Shigeyuki
広島大学原爆放射能医学研究所
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Yoshida Miki
Department of Hygiene Chemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science
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Sugihara K
Graduate School Of Biomedical Sciences Hiroshima University
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Yoshida M
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Kadota Tomoko
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Yoshida Mayumi
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Ohta Shigeru
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Ohta Shigeru
Institute Of Materials Science University Of Tsukuba
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Kitamura Shigeyuki
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Kadota Tomoko
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Yasuda Mineo
Department Of Hygiene Chemistry Faculty Of Pharmaceutical Sciences Tokyo University Of Science
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