Metabolic Activation of Proestrogens in the Environment by Cytochrome P450 System
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概要
- 論文の詳細を見る
Liver microsome-mediated activation of proestrogens in the environment is reviewed here. Proestrogens such as methoxychlor, trans-stilbene, diphenyl, diphenylmethane, 2,2-diphenylpropane, benzo[a]pyrene, benzophenone, 2-nitrofluorene (NF), chalcone, trans-4-phenyl-3-buten-2-one and styrene oligomers are negative in in vitro estrogen screening tests. However, those proestrogens exhibit estrogenic activity after metabolic activation by thee microsomal cytochrome P450 system. In these cases, hydroxylated derivatives of the compounds are formed as major metabolites, and these metabolites exhibit significant estrogenic activities. Thus, the estrogenic activities of proestrogenic compounds are a consequence of metabolism of the parent compounds. Various candidates for proestrogens among medicines and insecticides are also discussed.
- 公益社団法人日本薬学会の論文
- 2008-08-01
著者
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OHTA Shigeru
Graduate School of Biomedical Sciences, Hiroshima University
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FURUNO Nobuaki
Institute for Amphibian Biology, Graduate School of Science, Hiroshima University
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Shigeyuki Kitamura
Nihon Pharmaceutical University
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Kitamura Shigeyuki
広島大学 医学部総合薬学科生体機能分子動態学
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Kitamura Shigeyuki
広島大学 総合薬
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Kitamura Shigeyuki
広島大学原爆放射能医学研究所
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Furuno Nobuaki
Institute For Amphibian Biology Graduate School Of Science Hiroshima University
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Sanoh Seigo
Graduate School Of Biomedical Sciences Hiroshima University
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Kitamura Shigeyuki
Nihon Pharmaceutical University
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Sugihara Kazumi
Graduate School of Biomedical Sciences, Hiroshima University
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Sugihara K
Graduate School Of Biomedical Sciences Hiroshima University
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Fujimoto Nariaki
Research Institute For Radiation Biology And Medicine Hiroshima University
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Ohta S
Graduate School Of Biomedical Sciences Hiroshima University
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Kitamura Shigeyuki
Institute Of Pharmaceutical Science. Hiroshima University School Of Medicine
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Fujimoto N
Research Institute For Radiation Biology And Medicine Hiroshima University
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Ohta Shigeru
Graduate School Of Biomedical Sciences Hiroshima Univ.
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SUGIHARA Kazumi
Graduate School of Biomedical and Health Sciences, Hiroshima University
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SANOH Seigo
Graduate School of Biomedical and Health Sciences, Hiroshima University
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