Extremely High Drug-Reductase Activity Based on Aldehyde Oxidase in Monkey Liver
スポンサーリンク
概要
- 論文の詳細を見る
Drug-reducing ability of monkey liver cytosol was examined in this study. Monkey liver cytosol exhibited significant reductase activities toward zonisamide, sulindac and imipramine N-oxide in the presence of 2-hydroxy-pyrimidine or benzaldehyde, an electron donor to aldehyde oxidase. These activities were abolished by inhibitors of aldehyde oxidase, such as menadione. These reductase activities in monkeys were extremely high compared to those in other animals. The zonisamide reductase activity of monkey liver cytosol was about 40-fold higher than that of the liver microsomes. It appears that the high levels of aldehyde oxidase exists in monkey liver, and zonisamide, sulindac and imipramine N-oxide are mainly reduced by this enzyme, not by cytochrome P450.
- 公益社団法人日本薬学会の論文
- 2001-07-01
著者
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AKAGAWA Yasumasa
Department of Geriatric and Respiratory Medicine, Tohoku University Graduate School of Medicine
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Akagawa Yasumasa
広島大学 歯 歯補綴1
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HOSOKAWA Ryuji
Department of Advanced Prosthodontics, Hiroshima University School of Dentistry
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KITAMURA Shigeyuki
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Sugihara K
Graduate School Of Biomedical Sciences Hiroshima University
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Sugihara Kazumi
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Ohta Shigeru
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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NAKATANI Keiko
Division of Medicinal Chemistry, Graduate School of Biomedical Sciences, Hiroshima University
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Ohta S
Graduate School Of Biomedical Sciences Hiroshima University
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Ohta Shigeru
Institute Of Materials Science University Of Tsukuba
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NAKATANI Keiko
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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OHASHI Koji
Institute of Pharmaceutical Science, Hiroshima University School of Medicine
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Division Of Cervico-gnathostomatology Programs For Applied Bio
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Kitamura Shigeyuki
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Ohashi Koji
Institute Of Pharmaceutical Science Hiroshima University School Of Medicine
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Nakatani K
Division Of Medicinal Chemistry Graduate School Of Biomedical Sciences Hiroshima University
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Division Of Cervico-gnathostomatology Hiroshima University Gra
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Division Of Cervico-gnathostomatology Graduate School Of Biome
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AKAGAWA Yasumasa
Department of Removable Prosthodontics, Hiroshima University School of Dentistry
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