Bone formation ability of carbonate apatite-collagen scaffolds with different carbonate contents
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概要
- 論文の詳細を見る
Hydroxyapatite and carbonate apatites with different carbonate contents were synthesized, mixed with atelocollagen, and made into sponge scaffolds. The scaffolds were implanted into the bone sockets of the femurs of male New Zealand white rabbits for 2, 3, 12 and 24 weeks. carbonate apatite-collagen scaffold with 4.8 wt% carbonate content appeared to have similar crystallinity and chemical composition to human bone. When the scaffolds were implanted into the rabbit femurs, histological observation indicated that the carbonate apatites-collagen scaffolds with relatively higher carbonate contents were gradually deformed throughout the implantation period, and showed uniform surrounding bone after 24 weeks and could not be distinguished. The carbonate apatite-collagen scaffold with 4.8 wt% carbonate content showed the highest bone area ratio of all of the scaffolds. It is suggested that a carbonate apatite-collagen scaffold with carbonate content similar to that of human bone may have optimal bone formation ability.
- 日本歯科理工学会の論文
- 2009-03-01
著者
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OKAZAKI Masayuki
Department of Biomaterials Science, Graduate School of Biomedical Science, Hiroshima University
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HIRATA Isao
Department of Biomaterials Science, Graduate School of Biomedical Sciences, Hiroshima University
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AKAGAWA Yasumasa
Department of Geriatric and Respiratory Medicine, Tohoku University Graduate School of Medicine
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Hayashi Hidetaka
Department of Radiology, Tenri Hospital
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赤川 安正
広島大学大学院先端歯科補綴学研究室
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Akagawa Yasumasa
Hiroshima Univ. Hiroshima Jpn
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Kubo Takayasu
Clinic Of Oral Implants Hiroshima University Hospital
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Hayashi Hidetaka
Department Of Biomaterials Science Graduate School Of Biomedical Sciences Hiroshima University
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Graduate School Of Biomedical Sciences Hiroshima University
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Division Of Cervico-gnathostomatology Programs For Applied Bio
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Okazaki Masayuki
Department Of Fixed Prosthodontics Osaka University Graduate School Of Dentistry
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Okazaki Masayuki
Department Of Biomaterials Science Graduate School Of Biomedical Science Hiroshima University
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赤川 安正
広島大学大学院医歯薬学総合研究科
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Hayashi Kazuhiko
Clinic Of Oral Implants Hiroshima University Hospital
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Hirata Isao
Hiroshima Univ. Hiroshima Jpn
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YOKOTA Rie
Department of Oral and Maxillofacial Surgery, Miyazaki Medical College, University of Miyazaki
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Yokota Rie
Department Of Biomaterials Science Graduate School Of Biomedical Sciences Hiroshima University
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MATSUURA Ayumu
Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University
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DOI Kazuya
Clinic of Oral Implants, Hiroshima University Hospital
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MORITA Kouji
Department of Advanced Prosthodontics, Graduate School of Biomedical Sciences, Hiroshima University
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Doi Kazuya
Clinic Of Oral Implants Hiroshima University Hospital
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Morita Kouji
Department Of Advanced Prosthodontics Graduate School Of Biomedical Sciences Hiroshima University
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Matsuura Ayumu
Department Of Advanced Prosthodontics Graduate School Of Biomedical Sciences Hiroshima University
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Hirata Isao
Department Of Biomaterial Science Division Of Molecular Medical Science Hiroshima University Graduat
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Okazaki Masayuki
Hiroshima Univ. Hiroshima Jpn
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Okazaki Masayuki
Department Of Biomaterial Science Division Of Molecular Medical Science Hiroshima University Graduat
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Division Of Cervico-gnathostomatology Hiroshima University Gra
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Hayashi Hidetaka
Department Of Applied Chemistry Faculty Of Engineering Okayama University
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Division Of Cervico-gnathostomatology Graduate School Of Biome
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