Development of New Drug Delivery System for Implant Bone Augmentation Using a basic Fibroblast Growth Factor-gelatin Hydrogel Complex
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概要
- 論文の詳細を見る
This study sought to clarify the effectiveness of bFGF-gelatin hydrogel complex on bone regeneration around implants for the development of a new drug delivery system for bone augmentation. Twenty-four titanium implants (φ3.3 mm×1O mm) were placed into edentulous areas of the mandibles of four beagle dogs with the upper four screw threads exposed at buccal side. bFGF-gelatin hydrogel complex with 0, 0.1, 1, 10, 100μg bFGF or autogenous bone (as control) then filled the bone defect site to cover the exposed screw threads. after eight weeks, tissue specimens including implants were evaluated histologically and histomorphometrically. Histological observation showed new bone formation around exposed screw threads in the groups with 1, 10, 100 μg bFGF and autogenous bone-a striking contrast to the groups with contents of 0 and 0.1μg bFGF. These results thus suggested that bFGF-gelatin hydrogel complex using an optimum amount of bFGF was useful for bone augmentation around implants.
- 日本歯科理工学会の論文
著者
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tabata yasuhiko
Department of Biomaterials, Institute for Frontier Medical Science, Kyoto university
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Tabata Yasuhiko
Department Of Biomaterials Institute For Frontier Medical Sciences Kyoto University
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AKAGAWA Yasumasa
Department of Geriatric and Respiratory Medicine, Tohoku University Graduate School of Medicine
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赤川 安正
広島大学大学院先端歯科補綴学研究室
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Akagawa Yasumasa
Hiroshima Univ. Hiroshima Jpn
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HAYASHI Kazuhiko
Department of Pathology, Okayama University Medical School
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Kubo Takayasu
Clinic Of Oral Implants Hiroshima University Hospital
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Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Graduate School Of Biomedical Sciences Hiroshima University
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Division Of Cervico-gnathostomatology Programs For Applied Bio
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Hayashi Kazuhiko
Clinic Of Oral Implants Hiroshima University Hospital
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KUBO Takayasu
Department of Advanced Prosthodontics, Division of Cervico-Gnathostomatology, Programs for Applied B
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DOI Kazuya
Department of Advanced Prosthodontics, Division of Cervico-Gnathostomatology, Programs for Applied B
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Doi Kazuya
Clinic Of Oral Implants Hiroshima University Hospital
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Hayashi Kazuhiko
Department Of Gastroenterology Aichi Cancer Center Hospital
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Division Of Cervico-gnathostomatology Hiroshima University Gra
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Akagawa Yasumasa
Department Of Advanced Prosthodontics Division Of Cervico-gnathostomatology Graduate School Of Biome
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HAYASHI Kazuhiko
Department of Advanced Prosthodontics, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Hiroshima University Graduate School of Biomedical Sciences
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DOI Kazuya
Department of Advanced Prosthodontics, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Hiroshima University Graduate School of Biomedical Sciences
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KUBO Takayasu
Department of Advanced Prosthodontics, Division of Cervico-Gnathostomatology, Programs for Applied Biomedicine, Hiroshima University Graduate School of Biomedical Sciences
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