Potential of Drug Delivery Technology in Tissue Regeneration Therapy
スポンサーリンク
概要
- 論文の詳細を見る
As the third therapy following reconstructive surgery and organ transplantation, the therapy of regenerative medicine has been currently expected. The objective of regenerative medical therapy is to induce regeneration and repairing of defective and injured tissues based on the natural-healing potential of patients themselves. For successful tissue regeneration, it is undoubtedly indispensable to create a local environment that enables cells to efficiently proliferate and differentiate, resulting in the natural induction of tissue regeneration. Tissue engineering is a biomedical technology or methodology to build up this regeneration environment. For example, the technology of drug delivery system (DDS) enhances the biological functions of growth factors and the related genes for promoted tissue regeneration. This paper overviews the recent status of tissue regeneration based on the technology of growth factor release to emphasize significance of DDS technology in regenerative medical therapy.
- 硬組織再生生物学会の論文
著者
-
tabata yasuhiko
Department of Biomaterials, Institute for Frontier Medical Science, Kyoto university
-
Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
-
Tabata Yasuhiko
Institute For Frontier Medical Sciences Kyoto University
-
Tabata Yasuhiko
Department Of Oral And Maxillofacial Surgery The Nippon Dental University School Of Life Dentistry A
-
Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute. For Frontier Medical Sciences Kyot
-
Tabata Yasuhiko
Department Of Biomaterials Kyoto University
-
Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
-
Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
-
Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
-
Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
-
Yamaki Takahiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
関連論文
- PJ-335 Cell Therapy Improves Cardiac Dyssynchrony and Reduces the Transmural Extent of the Ischemic Regions in Chronic Myocardial Infarction(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japa
- 5 Cardiac Regenerative Hybrid-therapy Integrated via Human Autologous Cardiac Stem Cell and Biodegradable bFGF-incorporating Gelatin Hydrogel(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The 73
- OE-070 Post-Infarct Treatment with an Erythropoietin-Gelatin Hydrogel Patchlmproves Cardiac Function by Activating Prosurvival Signaling and exerting Antifibrotic and Angiogenic Effects(Genetics/Genetically engineered models/Gene therapy(M),Oral Presentat
- OJ-254 Erythropoietin Drug Delivery System protects the heart against myocardial infarction through activation of Akt and angiogenesis(Growth factor/Cytokine-2(H/M), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-335 Cell Therapy Improves Cardiac Dyssynchrony and Reduces the Transmural Extent of the Ischemic Regions in Chronic Myocardial Infarction(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japa
- 5 Cardiac Regenerative Hybrid-therapy Integrated via Human Autologous Cardiac Stem Cell and Biodegradable bFGF-incorporating Gelatin Hydrogel(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The 73
- OE-237 Dose-dependent Functional Recovery of Human Cardiac Stem Cell Transplantation Combined with Control-Delivery of Angiogenic Growth Factor in Chronic Myocardial Infarction(Regeneration(angiogenesis/myocardial regeneration)(01)(M),Oral Presentation(En
- 3 Human cardiac stem cell biotherapy Integrated with bFGF controlled-release : Two randomized, dose-ranging, controlled preclinical trial(Symposium 12 (SY-12) (M) Clinical Experiences of Regenerative Medicine in Cardiovascular Diseases,Special Program,The
- N/P Ratio Significantly Influences the Transfection Efficiency and Cytotoxicity of a Polyethylenimine/Chitosan/DNA Complex(Miscellaneous)
- Combination of Poly(ethylenimine) and Chitosan Induces High Gene Transfection Efficiency and Low Cytotoxicity(MISCELLANEOUS)
- PJ-335 Cell Therapy Improves Cardiac Dyssynchrony and Reduces the Transmural Extent of the Ischemic Regions in Chronic Myocardial Infarction(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japa
- 5 Cardiac Regenerative Hybrid-therapy Integrated via Human Autologous Cardiac Stem Cell and Biodegradable bFGF-incorporating Gelatin Hydrogel(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The 73
- OE-237 Dose-dependent Functional Recovery of Human Cardiac Stem Cell Transplantation Combined with Control-Delivery of Angiogenic Growth Factor in Chronic Myocardial Infarction(Regeneration(angiogenesis/myocardial regeneration)(01)(M),Oral Presentation(En
- 3 Human cardiac stem cell biotherapy Integrated with bFGF controlled-release : Two randomized, dose-ranging, controlled preclinical trial(Symposium 12 (SY-12) (M) Clinical Experiences of Regenerative Medicine in Cardiovascular Diseases,Special Program,The
- Alveolar bone tissue engineering using composite scaffolds for drug delivery
- PE-187 Sustained Release of Granulocyte Colony-Stimulating Factor Using Biodegradable Gelatin Hydrogel Improves Limb Ischemia(PE032,Peripheral Circulation/Vascular Disease (Pathophysiology, Basic) (H),Poster Session (English),The 73rd Annual Scientific Me
- PE-117 Sustained Release of Erythropoietin Using Biodegradable Gelatin Hydrogel Persistently Improves Lower Leg Ischemia without Evoking Polycytemia(Peripheral circulation/Vascular disease(03)(H),Poster Session(English),The 72nd Annual Scientific Meeting
- OE-070 Post-Infarct Treatment with an Erythropoietin-Gelatin Hydrogel Patchlmproves Cardiac Function by Activating Prosurvival Signaling and exerting Antifibrotic and Angiogenic Effects(Genetics/Genetically engineered models/Gene therapy(M),Oral Presentat
- PJ-335 Cell Therapy Improves Cardiac Dyssynchrony and Reduces the Transmural Extent of the Ischemic Regions in Chronic Myocardial Infarction(PJ057,Translational Science (Cardiac) (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japa
- 5 Cardiac Regenerative Hybrid-therapy Integrated via Human Autologous Cardiac Stem Cell and Biodegradable bFGF-incorporating Gelatin Hydrogel(Therapeutic Strategy for Severe Heart Failure-From LVAD to Heart Transplantation-,Symposium 11 (SY-11) (H),The 73
- OE-237 Dose-dependent Functional Recovery of Human Cardiac Stem Cell Transplantation Combined with Control-Delivery of Angiogenic Growth Factor in Chronic Myocardial Infarction(Regeneration(angiogenesis/myocardial regeneration)(01)(M),Oral Presentation(En
- 3 Human cardiac stem cell biotherapy Integrated with bFGF controlled-release : Two randomized, dose-ranging, controlled preclinical trial(Symposium 12 (SY-12) (M) Clinical Experiences of Regenerative Medicine in Cardiovascular Diseases,Special Program,The
- Preparation of injectable 3D-formed β-tricalcium phosphate bead/alginate composite for bone tissue engineering
- OJ-314 Drug Delivery System Using Erythropoietin Gelatin Hydrogel Sheet Decreases Myocardial Infarct Size and Improves Left Ventricular Function and Remodeling(Growth factor/Cytokine-1 (H) OJ53,Oral Presentation (Japanese),The 70th Anniversary Annual Scie
- Controlled Release of Matrix Metalloproteinase-1 Plasmid DNA Prevents Left Ventricular Remodeling in Chronic Myocardial Infarction of Rats
- OE-018 E-NTPDase Gene Eluting Stent Prevents Subacute Thrombosis in the Balloon-injured Arteries of Rabbit(Acute coronary syndrome, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- Fabrication of three-dimensional cell scaffolds with spatial gradients of biomolecules
- PE-084 In Vitro Myogenic Differentiation of Bone Marrow Stem Cells by Condition Medium(Tissue Engineering (H) : PE15)(Poster Session (English))
- Areal Distribution of Preferential Alignment of Biological Apatite (BAp) Crystallite on Cross-Section of Center of Femoral Diaphysis in Osteopetrotic (op/op) Mouse
- Texture of Biological Apatite Crystallites and the Related Mechanical Function in Regenerated and Pathological Hard Tissues(International Symposium of Maxillofacial & Oral Regenerative Biology in OKAYAMA 2005)
- Texture of Biological Apatite Crystallites and the Related Mechanical Function in Regenerated and Pathological Hard Tissues(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Recent advances in tissue engineering for regeneration of oral tissues
- Enhanced Osteoinduction by Biodegradable Gelatin-β-tricalcium Phosphate Sponge Capable for Bone Morphogenetic Protein Release(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Enhanced osteoinduction by biodegradable gelatin-tricalcium phosphate sponge incorporating bone morphogenetic protein(13^ Annual Meeting of the Society for Hard Tissue Regenerative Biology)
- 13.Comparison in the induction of bone regeneration by controlled release of bone morphogenetic protein among different animal species(12th Annual Meeting of the Society of Hard Tissue Biology)
- Bioartificial Pancreas Transplantation at Prevascularized Intermuscular Space : Effect of Angiogenesis Induction on Islet Survival
- Letters to the Editor
- Letters to the Editor
- Effect of Aminated Gelatin on the Nasal Absorption of Insulin in Rats(Biopharmacy)
- Sustained Release of Prostaglandin E_1 Potentiates the Impaired Therapeutic Angiogenesis by Basic Fibroblast Growth Factor in Diabetic Murine Hindlimb Ischemia
- New Therapeutic Approach for Impaired Arteriogenesis in Diabetic Mouse Hindlimb Ischemia
- A Novel Approach to Therapeutic Angiogenesis for Patients With Critical Limb Ischemia by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel : An Initial Report of the Phase I-IIa Study
- 4 Control-release of MMP-1 Plasmid DNA Improved Contractility and Altered Na/Ca Exchange of Cardiomyocytes Isolated from Rat Chronic Myocardial Infarction Heart(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 6 Clinical Trials for Ischemic Hearts and Limbs Using Control-released Basic Fibroblast Growth Factor(Clinical Trials of Regeneration Therapy in Japan, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- 4 Towards New Era for Regenerative Medicine in Cardiovascular Area(Regeneration Therapy Using Tissue Engineering, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Combined Treatment With Sustained-Release Basic Fibroblast Growth Factor and Heparin Enhances Neovascularization in Hypercholesterolemic Mouse Hindlimb Ischemia
- Sustained-Release Erythropoietin Ameliorates Cardiac Function in Infarcted Rat-Heart Without Inducing Polycythemia
- Combined Treatment of Sustained-Release Basic Fibroblast Growth Factor and Sarpogrelate Enhances Collateral Blood Flow Effectively in Rabbit Hindlimb Ischemia
- PJ-118 Combined Treatment of Sustained-release Basic Fibroblast Growth Factor and Heparin Enhances Angiogenesis in Hypercholesterolemic Mouse Hindlimb Ischemia(Peripheral circulation-8 (H) PJ20,Poster Session (Japanese),The 70th Anniversary Annual Scienti
- Induction of Arteriogenesis in Chronic Ischemic Myocardium by a Combination of bFGF and Omentopexy as Extra Cardiac Blood Source(Vascular Regeneration (M), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Therapeutic angiogenesis by the controlled release of basic fibroblast growth factor for ischemic limb and heart injury : toward safety and minimal invasiveness
- Dual Release of Basic Fibroblast Growth Factor and Hepatocyte Growth Factor from Biodegradable Collagen Microsphere Synergistically Enhances Therapeutic Angiogenesis and Promotes Vascular Maturation in Critical Limb Ischemia
- Targeting of Plasmid DNA to Renal Interstitial Fibroblasts by Cationized Gelatin(Biopharmacy)
- Cranial Bone Regeneration by Controlled Release of Platelet Growth Factors from Biodegradable Hydrogel(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Augmented Bone Regeneration Activity of Platelet-Rich Plasma by Biodegradable Hydrogel(13^ Annual Meeting of the Society for Hard Tissue Regenerative Biology)
- 12.Experimental study on a newly modified preparation of prefabricated vascularized bone graft for bone reconstruction(12th Annual Meeting of the Society of Hard Tissue Biology)
- OJ-046 Aspirin Acts as a Protective Agent against Myocardial Cell Apoptosis via the Activation of Extracellular Signal-Regulated Kinase and P300(Antithrombofic Ttherapy (H) : OJ6)(Oral Presentation (Japanese))
- Control-Released Hepatocyte Growth Factor (HGF) Prevents Myocardial Fibrosis in Spontaneously Hypertensive Rats
- The Regenerated Cardiac Myocytes Derived from Bone Marrow Adult Stem Cells Cultured with Cardiac Condition Medium in Vitro
- Biodegradable microspheres targeting mucosal immune-regulating cells : new approach for treatment of inflammatory bowel disease
- Intestinal drug delivery systems with biodegradable microspheres targeting mucosal immune-regulating cells for chronic inflammatory colitis
- Phagocytes Transfected with Biodegradable Gelatin Allow Tissue-Targeted and Less Invasive Gene Therapy
- Regenerative medical therapy from the viewpoint of biomaterials
- 3 Functional Analysis of Novel Antimicrobial Peptide, AG (Angiogenic Peptide)-30, with Angiongenic Property, toward Clinical Application(The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Properties of osteoinduction and BMP-2 release in β-TCP from spongy bone(Oral Session,The 16th Annual Meeting of the Society for Hard Tissue Regenerative Biology in Matsumoto Dental University)
- Properties of osteoinduction and BMP-2 release in functionally graded HAp(15thAnnual Meeting of the Society for Hard Tissue Regenerative Biology,Session 2)
- A novel bFGF-GH injection therapy for two patients with severe ischemic limb pain
- ENHANCED COLLAGEN FORMATION IN MICE WITH CONTROLLED RELEASE OF FROZEN-POOLED PLATELET-DERIVED FACTORS
- Collagen-poly glycolic acid hybrid matrix with basic fibroblast growth factor accelerated angiogenesis and granulation tissue formation in diabetic mice
- Developing "Bio-CABG"-Revascularizing Numerous Coronary Branches by the Arterial Graft
- OE-100 Protein Therapy Using Control-Released b-FGF in Patients with Ischemic Limbs : a Possible Alternative to Bone Marrow Mononuclear Cell Implantation(Regeneration (angiogenesis/myocardial regeneration)-1, The 71st Annual Scientific Meeting of the Japa
- PJ-002 Effect of Combination Therapy with Sustained-Release bFGF and G-CSF on Angiogenesis and Cardiac Function in Myocardial Ischemia(Acute myocardial infarction, basic(02)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese
- The Gene Transfection using Cell Attachment Peptides for Gene Therapy
- Cationized gelatin delivery of a plasmid DNA expressing small interference RNA for VEGF inhibits murine squamous cell carcinoma
- S2-5 Inhibition of Heat shock protein 47 expression as a therapy for peritoneal sclerosis(THE 46TH ANNUAL MEETING OF THE JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY)
- Transcatheter Arterial Embolization Using poly-L-lactic Acid Microspheres
- Influence of basic fibroblast growth factor in the solution and adsorbed form on the proliferation and differentiation of cells
- Experimental tissue regeneration by DDS technology of bio-signaling molecules
- Fabrication of Non-woven Mats of Gelatin/Poly(L-lactic acid) Composites by Electrospinning and Their Application for Scaffold of Cell Proliferation
- Development of New Drug Delivery System for Implant Bone Augmentation Using a basic Fibroblast Growth Factor-gelatin Hydrogel Complex
- Potential of Drug Delivery Technology in Tissue Regeneration Therapy
- 2 Cadiovascular Regeneration Therapy Based on DDS Technology(Latest Development of Nanotechnology Revolutionizes Treatments of Cardiovascular Diseases,Topic 3 (TP-3) (H),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PE-309 The Experiment for improving the patency of the vein graft for CABG(Cardiovascular Surgery/CABG 3 (IHD) : PE53)(Poster Session (English))
- Frontier of Tissue Engineering Indispensable for Cardiovascular Regeneration Therapy(Mashimo Memorial Lecture,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- Mechanisms of HERS formation and development of tooth root formation technology(15thAnnual Meeting of the Society for Hard Tissue Regenerative Biology,Session 2)
- Regeneration induction therapy based on DDS technology of growth factors(15thAnnual Meeting of the Society for Hard Tissue Regenerative Biology,Session 2)
- Design of Tissue-engineered Nano-Scaffold Using Peptide Amphiphile for Regenerative Medicine
- Selective Differentiation of Cardiomyocyte Cells by Using Peptide Amphiphile Nanofibers
- Cell Adhesion Scaffold Using Self-assemble β-strand Peptides
- 1 Hybrid Cell-gene Therapy for Pulmonary Hypertension Based on Phagocytosing Action of Endothelial Progenitor Cells(Plenary Session 8 (PL8) (IHD) : Toward Optimal Transplant Programs in Japan : from Cellular, Tissue and Solid Organ Aspects)(Special Progra
- Turn-on Detection of Targeted Biochemical Reactions by Triple Resonance NMR Analysis Using Isotope-labeled Probe
- Regenerative Medical Therapy for Hard Tissues Based on Tissue Engineering(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Non-viral vectors for cancer therapy
- Initial bone regeneration around fenestrated implants in Beagle dogs using basic fibroblast growth factor-gelatin hydrogel complex with varying biodegradation rates
- Treatment of experimental osteonecrosis of the hip in adult rabbits with a single local injection of recombinant human FGF-2 microspheres
- Significant Role of Tissue Engineering in Regenerative Medicine
- Present status of regenerative medicine based on tissue engineering(12th Annual Meeting of the Society of Hard Tissue Biology)
- 4 Regeneration Therapy Based on Tissue Engineering(Plenary Session 5 (PL5) (M) : Regeneration Therapy : Current Status and Future Perspectives)(Special Program)
- Novel approach to ischemic skin ulcer in systemic lupus erythematosus : Therapeutic angiogenesis by controlled-release basic fibroblast growth factor
- Effect of Compound of Gelatin Hydrogel Microsphere Incorporated with Platelet-Rich-Plasma and Alginate on Sole Defect in Cattle