Combined Treatment of Sustained-Release Basic Fibroblast Growth Factor and Sarpogrelate Enhances Collateral Blood Flow Effectively in Rabbit Hindlimb Ischemia

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概要

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• Background The effectiveness of sustained-release basic fibroblast growth factor (bFGF) in potentiating arteriogenesis and angiogenesis was evaluated, as well as determining whether chronic oral administration of sarpogrelate, a serotonin blocker, would further increase collateral blood flow in the rabbit hindlimb following surgical induction of ischemia by femoral artery extraction. Methods and Results Two weeks after femoral artery removal, the rabbits were assigned to 1 of 4 experimental groups and treated for 4 weeks: group A, no treatment; group B, supplemented with diet containing sarpogrelate; group C, single intramuscular injection of sustained-release form of bFGF microspheres; group D: combined treatment with sustained-release bFGF and sarpogrelate. Endpoint measurements performed at 6 weeks found that the ischemic hindlimb blood flow was significantly improved in the rabbits that received sustained-release bFGF, with a further significant improvement in those with the additional administration of sarpogrelate. Angiographic assessment revealed augmented density of collateral vessels in the medial thigh region in the rabbits given the combined treatment. Conclusions The findings demonstrate that sustained-release bFGF stimulated the development of collateral vessels, and additional administration of sarpogrelate produced a further improvement in hindlimb blood flow in the rabbit hindlimb ischemia model.

• 社団法人日本循環器学会の論文
• 2006-08-20

著者

• Chandra Shyamal

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Tabata Y

  Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto

• komeda Masashi

  Department of Cardiovascular Surgery, Kyoto University

• Fujita Masatoshi

  School of Health Sciences, Faculty of Medicine, Kyoto University

• Fujita M

  Human Health Sciences Graduate School Of Medicine Kyoto University

• Fujita M

  School Of Health Sciences Faculty Of Medicine Institute For Frontier Medical Sciences Kyoto Universi

• Tabata Y

  Department Of Cardiology Gifu University Graduate School Of Medicine

• Marui Akira

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Fujita M

  School Of Health Sciences Faculty Of Medicine Kyoto University

• Sakaguchi Hisashi

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Sakaguchi Hisashi

  Department Of Cardiovascular Surgery Graduate School Of Medical Sciences Kumamoto University

• Komeda M

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Komeda Masashi

  京都大学 医研究 循環病態

• Komeda Masashi

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• FUJITA MASATOSHI

  Otowa Hospital

• Komeda Masashi

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Arai Yoshio

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Tabata Yasuhiko

  Institute For Frontier Medical Sciences Kyoto University

• Huang Yuhong

  Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine

• Hirose Keiichi

  Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine

• Fujita Masatoshi

  Department Of Human Health Sciences Graduate School Of Medicine Kyoto University

• Fujita Masatoshi

  School Of Health Sciences Faculty Of Medicine Kyoto University

• Marui Akira

  Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University

• Komeda Masashi

  Department Of Mechanical Engineering Faculty Of Engineering Setsunan University

• Tabata Yasuhiko

  Institute For Frontier Medical Science Kyoto University

• Marui Akira

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Huang Yuhong

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Hirose Keiichi

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Hirose Keiichi

  Department Of Cardiovascular Surgery Hyogo Prefectural Amagasaki Hospital

• Fujita Masatoshi

  Iii Div. Dept Of Intern. Med. Kyoto Univ.

• Komeda Masashi

  Division Of Cardiovascular Surgery Kyoto University School Of Medicine

• Fujita Masatoshi

  Dep. Of Human Health Sciences Graduate School Of Medicine Kyoto Univ.

• Tabata Yasuhiko

  Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto

• Komeda Masashi

  Department Of Cardiovasucular Surgery Graduate School Of Medicine

• Arai Yoshio

  Department Of Bacteriology Saitama Medical School

• Fujita Masatoshi

  Department Of Human Health Sciences Division Of Bioinformatics And Chemical Genomics Graduate School Of Pharmaceutical Sciences Kyoto University

• Sakaguchi Hisashi

  Department Of Cardiovascular Surgery Graduate School Of Medical Science Kumamoto University

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