Repeated Implantation is a More Effective Cell Delivery Method in Skeletal Myoblast Transplantation for Rat Myocardial Infarction

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概要

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• Background Several clinical trials are underway to determine whether autologous skeletal myoblast transplantation is an effective and safe therapeutic strategy for severe heart failure due to myocardial infarction (MI). It remains unclear whether repeated skeletal myoblast implantation is a feasible and effective cell delivery method for the infarcted myocardium. Methods and Results Four weeks after a coronary ligation, male syngeneic Lewis rats were assigned to 3 treatment groups: 3 episodes of skeletal myoblasts (6×10^6) transplantation (group I), a bolus transplantation of myoblasts (18×10^6) (group II), or culture medium injection (group III). Eight weeks after the first treatment, echocardiography, cardiac catheterization and histological examination were performed to compare the therapeutic effects on left ventricular (LV) systolic and diastolic functions, and the engrafted myoblast volume. Repeated myoblast implantation significantly improved LV function and resulted in significantly larger engrafted volume and LV contractility compared with a bolus transplantation with the same number of myoblasts. Conclusions Repeated skeletal myoblast transplantation is a safe and effective therapeutic strategy for the infarcted myocardium.

• 社団法人日本循環器学会の論文
• 2006-08-20

著者

• IKEDA Tadashi

  Department of Surgery, Keio University School of Medicine

• komeda Masashi

  Department of Cardiovascular Surgery, Kyoto University

• Fujita Masatoshi

  School of Health Sciences, Faculty of Medicine, Kyoto University

• Fujita Masatoshi

  国立病院機構京都医療センター 展開医療研究部

• Fujita M

  Human Health Sciences Graduate School Of Medicine Kyoto University

• Fujita M

  School Of Health Sciences Faculty Of Medicine Institute For Frontier Medical Sciences Kyoto Universi

• Nakajima Hiroyuki

  Department of Cardiology, National Cardiovascular Center

• Takenaka Kotoe

  京都大学 院循環器内科

• Nakajima Hiroyuki

  Department Of Organ Transplantation Cardiovascular Surgery National Cardiovascular Center

• Tambara Keiichi

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Fujita M

  School Of Health Sciences Faculty Of Medicine Kyoto University

• Tambara K

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Tambara Keiichi

  京都大学 医学研究科循環器外科

• Tambara Keiichi

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• TOMITA Shinji

  Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center

• Komeda M

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Komeda Masashi

  京都大学 医研究 循環病態

• Komeda Masashi

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• FUJITA MASATOSHI

  Otowa Hospital

• Tomita Shinji

  Department Of Cardiovascular Surgery Nagara Medical Center

• Tomita Shinji

  Department Of Cardiovascular Surgery And Cardiology Nagara Medical Center

• Komeda Masashi

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• LIN Xue

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Kanemitsu Naoki

  Department of Cardiovascular Surgery, Graduate School of Medicine

• Premaratne Goditha

  Department of Cardiovascular Surgery, Graduate School of Medicine

• Ikeda Tadashi

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Nakajima Hiroyuki

  Department Of Cardiovascular Surgery Mitsubishi Kyoto Hospital

• Sakaguchi Genichi

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Fujita Masatoshi

  School Of Health Sciences Faculty Of Medicine Kyoto University

• Komeda Masashi

  Department Of Mechanical Engineering Faculty Of Engineering Setsunan University

• Sakaguchi Genichi

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Lin Xue

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Kanemitsu Naoki

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Kanemitsu Naoki

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Fujita Masatoshi

  Iii Div. Dept Of Intern. Med. Kyoto Univ.

• Ishii Takahiro

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Premaratne Goditha

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Komeda Masashi

  Division Of Cardiovascular Surgery Kyoto University School Of Medicine

• Fujita Masatoshi

  Dep. Of Human Health Sciences Graduate School Of Medicine Kyoto Univ.

• Komeda Masashi

  Department Of Cardiovasucular Surgery Graduate School Of Medicine

• Nakajima Hiroyuki

  Department Of Cardiology National Cerebral And Cardiovascular Center

• Ikeda Tadashi

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Tomita Shinji

  Department Of Cardiovascular Dynamics National Cerebral And Cardiovascular Center

• Lin Xue

  Department Of Bioscience And Bioengineering Dalian University Of Technology

• Kanoh Tatsuji

  順天堂大学 医学部循環器内科学

• Fujita Masatoshi

  Department Of Human Health Sciences Division Of Bioinformatics And Chemical Genomics Graduate School Of Pharmaceutical Sciences Kyoto University

• NAKAJIMA HIROYUKI

  Department of Cardiovascular Surgery, Mitsubishi Kyoto Hospital

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