Delivery Route in Bone Marrow Cell Transplantation Should be Optimized According to the Etiology of Heart Disease
スポンサーリンク
概要
- 論文の詳細を見る
Background Recent studies have revealed that bone marrow cell (BMC) transplantation is effective not only for myocardial infarction (MI), but also for dilated cardiomyopathy (DCM). However, the method of administering donor cells remains unknown, and may differ between MI and DCM. In the present study, intramyocardial (IM) injection and intravenous (IV) delivery of BMC were compared in each etiological model. Methods and Results MI was induced in 72 mice and DCM in another 36 mice by doxorubicin. BMCs were administered IV or IM in an acute MI (AMI), old MI (OMI) or DCM model. In the AMI model, left ventricular (LV) remodeling was reduced in both the IM- and IV-groups, but only in the IM-group in the OMI model. In the DCM model, the LV dimension of the IV-group was smaller than that of the IM-group. Histological examination showed that green fluorescent protein (GFP) cells were equally distributed in the infarct area of the IV- and IM-groups in AMI, and in the IM-group in the OMI model. In the DCM model, GFP cells were diffusely scattered throughout the ventricular wall in the IV-group, but were confined to the injection site in the IM-group. Conclusions In OMI, IM delivery of BMCs was more effective than IV; however, IV delivery was superior in DCM. Delivery route should be selected according to the etiology of heart disease to optimize the efficacy of BMC transplantation.
- 社団法人日本循環器学会の論文
- 2008-08-20
著者
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IKEDA Tadashi
Department of Surgery, Keio University School of Medicine
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NAKAHATA Tatsutoshi
Department of Pediatrics, Kyoto University
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komeda Masashi
Department of Cardiovascular Surgery, Kyoto University
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Arai Masazumi
Department Of Cardiology Gifu University Graduate School Of Medicine
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Nakajima Hiroyuki
Department of Cardiology, National Cardiovascular Center
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Takenaka Kotoe
京都大学 院循環器内科
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NISHIMURA KAZUNOBU
Department of Cardiovascular Surgery
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Nakajima Hiroyuki
Department Of Organ Transplantation Cardiovascular Surgery National Cardiovascular Center
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Marui A
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Matsumori A
Department Of Cardiovascular Medicine Kyoto University Graduate School Of Medicine
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Marui Akira
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
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Tambara Keiichi
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
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Tambara K
Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University
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Tambara Keiichi
京都大学 医学研究科循環器外科
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Tambara Keiichi
Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University
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Komeda M
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Komeda Masashi
京都大学 医研究 循環病態
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Komeda Masashi
Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University
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Miura Aya
Dep. Of Cardiovascular Medicine Graduate School Of Medicine Dentistry And Pharmaceutical Sciences Ok
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Akao Masaharu
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Komeda Masashi
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Matsumori Akira
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Matsumori Akira
The Third Division Department Of Internal Medicine Kyoto University And Department Of Medicine Beth
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SAKAKIBARA Yutaka
Department of Cardiovascular Surgery, Kyoto University
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LIN Xue
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
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Kanemitsu Naoki
Department of Cardiovascular Surgery, Graduate School of Medicine
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Premaratne Goditha
Department of Cardiovascular Surgery, Graduate School of Medicine
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Ikeda Tadashi
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Nakajima Hiroyuki
Department Of Cardiovascular Surgery Mitsubishi Kyoto Hospital
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Yoshimoto Momoko
Department of Pediatrics, Graduate School of Medicine, Kyoto University
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Sakaguchi Genichi
Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University
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Marui Akira
Department Of Cardiovascular Medicine Graduate School Of Medicine Kyoto University
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Nakahata Tatsutoshi
Department Of Pediatrics Graduate School Of Medicine Kyoto University
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Komeda Masashi
Department Of Mechanical Engineering Faculty Of Engineering Setsunan University
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Sakaguchi Genichi
Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University
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Marui Akira
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Lin Xue
Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University
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Kanemitsu Naoki
Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University
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Kanemitsu Naoki
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Nishimura Kazunobu
Department Of Cardiovascular Surgery Tenri Hospital
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Yoshimoto Momoko
Department Of Pediatrics Graduate School Of Medicine Kyoto University
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Nakahata Tatsutoshi
Department Of Clinical Oncology The Institute Of Medical Science The University Of Tokyo
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Arai Masazumi
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Matsumori Akira
Department Of Cardiology Kyoto University
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Ishii Takahiro
Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine
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Sakakibara Yutaka
Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University
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Sakakibara Yutaka
Department Of Applied Chemistry Faculty Of Engineering Kyushu University
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Premaratne Goditha
Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University
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Komeda Masashi
Division Of Cardiovascular Surgery Kyoto University School Of Medicine
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Matsumori Akira
The Third Division Department Oflnternal Medicine Kyoto University
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Komeda Masashi
Department Of Cardiovasucular Surgery Graduate School Of Medicine
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Arai Masazumi
Division Of Cardiology Kyoto Medical Center National Hospital Organization
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Marui Akira
Division Of Cardiology Kyoto Medical Center National Hospital Organization
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Nakajima Hiroyuki
Department Of Cardiology National Cerebral And Cardiovascular Center
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Ikeda Tadashi
Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University
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Matsumori Akira
Department Of Cardiovascular Medicne Kyoto University Graduate School Of Medicine
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Lin Xue
Department Of Bioscience And Bioengineering Dalian University Of Technology
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Kanoh Tatsuji
順天堂大学 医学部循環器内科学
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Matsumori Akira
Department Of Cardiovascular Surgery Division Of Bioinformatics And Chemical Genomics Graduate School Of Pharmaceutical Sciences Kyoto University
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NAKAJIMA HIROYUKI
Department of Cardiovascular Surgery, Mitsubishi Kyoto Hospital
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Nakahata Tatsutoshi
Department of Pediatrics, Graduate School of Medicine, Kyoto University
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