Sustained-Release Erythropoietin Ameliorates Cardiac Function in Infarcted Rat-Heart Without Inducing Polycythemia

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概要

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• Background The usefulness of sustained-release erythropoietin for improving left ventricular (LV) function without polycythemia was evaluated in a rat chronic myocardial infarction model. Methods and Results Four weeks after left coronary artery ligation, 50 Sprague-Dawley rats were assigned to 5 groups (n=10, each). Control group had a gelatin sheet (20×20mm) containing saline applied to the infarct area, whereas the 4 treatment groups had gelatin sheets incorporating erythropoietin 0.1U, 1U, 10U and 100U, respectively. Endpoint measurements performed at 8 weeks after the coronary ligation revealed that the fractional area change was larger for erythropoietin 1U and 10U than in the other 3 groups. The LV end-systolic elastance and the time constant of isovolumic relaxation were better for erythropoietin 1U and 10U than in the other 3 groups. The density of vessels larger than 50μm in diameter was the highest in the erythropoietin 1U group. The number of red blood cells was significantly increased in groups receiving erythropoietin 10U and 100U. Conclusions Gelatin hydrogel sheets incorporating 1U erythropoietin improved LV function without inducing polycythemia in a rat chronic myocardial infarction model.

• 社団法人日本循環器学会の論文
• 2006-12-20

著者

• tabata yasuhiko

  Department of Biomaterials, Institute for Frontier Medical Science, Kyoto university

• IKEDA Tadashi

  Department of Surgery, Keio University School of Medicine

• Tabata Y

  Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto

• komeda Masashi

  Department of Cardiovascular Surgery, Kyoto University

• Fujita Masatoshi

  School of Health Sciences, Faculty of Medicine, Kyoto University

• Fujita Masatoshi

  国立病院機構京都医療センター 展開医療研究部

• Fujita M

  Human Health Sciences Graduate School Of Medicine Kyoto University

• Fujita M

  School Of Health Sciences Faculty Of Medicine Institute For Frontier Medical Sciences Kyoto Universi

• Tabata Y

  Department Of Cardiology Gifu University Graduate School Of Medicine

• Takenaka Kotoe

  京都大学 院循環器内科

• Kimura Yu

  Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University

• Tambara Keiichi

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Fujita M

  School Of Health Sciences Faculty Of Medicine Kyoto University

• Tambara K

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Tambara Keiichi

  京都大学 医学研究科循環器外科

• Tambara Keiichi

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Komeda M

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Komeda Masashi

  京都大学 医研究 循環病態

• Komeda Masashi

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• FUJITA MASATOSHI

  Otowa Hospital

• Komeda Masashi

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Tabata Yasuhiko

  Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto

• LIN Xue

  Department of Cardiovascular Surgery, Graduate School of Medicine, Kyoto University

• Kanemitsu Naoki

  Department of Cardiovascular Surgery, Graduate School of Medicine

• Premaratne Goditha

  Department of Cardiovascular Surgery, Graduate School of Medicine

• Nagasawa Atsushi

  Department of Cardiovascular Surgery, Graduate School of Medicine

• Ikeda Tadashi

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Fujita Masatoshi

  School Of Health Sciences Faculty Of Medicine Kyoto University

• Komeda Masashi

  Department Of Mechanical Engineering Faculty Of Engineering Setsunan University

• Lin Xue

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Kimura Yu

  Frontier Medical Sciences Kyoto University

• Kimura Yu

  Department Of Biomaterials Field Of Tissue Engineering

• Kimura Yu

  Department Of Biomaterials Institute For Frontier Medical Sciences Kyoto University

• Kanemitsu Naoki

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Kanemitsu Naoki

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Fujita Masatoshi

  Iii Div. Dept Of Intern. Med. Kyoto Univ.

• Ishii Takahiro

  Department Of Cardiovascular Surgery Kyoto University Graduate School Of Medicine

• Nagasawa Atsushi

  Department Of Cardiovascular Surgery Graduate School Of Medicine

• Premaratne Goditha

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Komeda Masashi

  Division Of Cardiovascular Surgery Kyoto University School Of Medicine

• Fujita Masatoshi

  Dep. Of Human Health Sciences Graduate School Of Medicine Kyoto Univ.

• Tabata Yasuhiko

  Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto

• Komeda Masashi

  Department Of Cardiovasucular Surgery Graduate School Of Medicine

• Ikeda Tadashi

  Department Of Cardiovascular Surgery Graduate School Of Medicine Kyoto University

• Lin Xue

  Department Of Bioscience And Bioengineering Dalian University Of Technology

• Kanoh Tatsuji

  順天堂大学 医学部循環器内科学

• Fujita Masatoshi

  Department Of Human Health Sciences Division Of Bioinformatics And Chemical Genomics Graduate School Of Pharmaceutical Sciences Kyoto University

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