Effect of Aminated Gelatin on the Nasal Absorption of Insulin in Rats(Biopharmacy)
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概要
- 論文の詳細を見る
Absorption enhancers, which increase the permeability of drugs through epithelial membranes without damaging them, are especially useful for intranasal administration of peptide drugs. In this study, aminated gelatins, candidate enhancers, having different numbers of amino groups were prepared from gelatin (H-gelatin, isoelectric point=9.0, MW 100 kDa) and a partial gelatin hydrolysate (L-gelatin, isoelectric point=8.0, MW 5 kDa), and the enhancing effects on the nasal absorption of insulin, used as a model peptide drug, and 5(6)-carboxyfluorescein (CF), a paracellular marker, were examined in rats. The enhancing effect on insulin and CF depends on the MW and number of amino groups. A high correlation between the enhancing effects on insulin and CF was observed and this suggests that an increase in the paracellular permeability is the mechanism governing the nasal absorption-enhancement of aminated gelatins, at least as far as insulin and CF are concerned. The enhancing mechanism might be shared with other cationic polymers having absorption-enhancing effects.
- 社団法人日本薬学会の論文
- 2005-03-01
著者
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tabata yasuhiko
Department of Biomaterials, Institute for Frontier Medical Science, Kyoto university
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Morimoto Kazuhiro
Hokkaido Pharmaceutical University School of Pharmacy
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HAYASHI Masahiro
Department of Dermatology, Yamagata University School of Medicine
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Chono S
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
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Chono Sumio
Department Of Pharmaceutics Hokkaido College Of Pharmacy
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Seki T
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
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Seki Toshinobu
Hokkaido Pharmaceutical University School Of Pharmacy
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Tabata Yasuhiko
Department Of Biomaterials Field Of Tissue Engineering Institute For Frontier Medical Sciences Kyoto
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Tabata Y
Kyoto Univ. Kyoto Jpn
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KANBAYASHI Hiroshi
Hokkaido College of Pharmacy
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NAGAO Tomonobu
Hokkaido College of Pharmacy
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CHONO Sumio
Hokkaido College of Pharmacy
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TOMITA Mikio
Department of Biopharmaceutics, Tokyo College of Pharmacy
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Seki T
Hokkaido Pharmaceutical University School Of Pharmacy
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Morimoto Kazuhiro
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
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Morimoto K
Hokkaido Pharmaceutical University School Of Pharmacy
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Tomita Mikio
Department Of Biopharmaceutics School Of Pharmacy Tokyo University Of Pharmacy And Life Science
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Tomita Mikio
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Tomita Mikio
Department Of Drug Absorption And Pharmacokinetics School Of Pharmacy Tokyo University Of Pharmacy A
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Hayashi Masahiro
Department Of Biological Production And Enviromental Science Faculty Of Agriculture The University O
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Hayashi Masahiro
Department Of Biopharmaceutics Tokyo College Of Pharmacy
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Hayashi Masahiro
Department of Absorption and Pharmacokinetics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
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