Measurement of Diffusion Coefficients of Parabens and Steroids in Water and 1-Octanol
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概要
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Diffusion coefficients (D) of parabens and steroids in water and 1-octanol were determined by using the chromatographic broadening method at 37℃, and the relationships between the D values and the physicochemical properties of the drugs were discussed. The D values in 1-octanol were lower than those in water because of the higher viscosity of 1-octanol. The D values depend on not only the molecular weight (MW), but also the lipophilicity of the drugs in water and on the ability for hydrogen-bonding in 1-octanol. When the lipophilic index (LI), calculated from the retention time using in a reverse-phase column, was used as a parameter of drug lipophilicity, the following equation was obtained for D in water (D_w); logD_w=-0.215・logMW-0.077・logLI-4.367. When the hydrogen bond index (HI), the logarithm of the ratio of the partition coefficient of the drugs in 1-octanol and cyctohexane, was used as an index of hydrogen-bonding, the following equation was obtained for D in 1-octanol (D_0); logD_0=-0.690・logMW-0.074・logHI-4.085.
- 公益社団法人日本薬学会の論文
- 2003-06-01
著者
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持田 純子
城西大学
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Mochida Junko
Faculty Of Pharmaceutical Sciences Josai University
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Hosoya Osamu
Research Institute of TTS Technology
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Morimoto Kazuhiro
Hokkaido Pharmaceutical University School of Pharmacy
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Juni Kazuhiko
Faculty of Pharmaceutical Sciences, Josai University
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Hosoya O
Department Of Pharmacy Japanese Red Cross Hospital Omori
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Hosoya O
Niigata Univ. Niigata Jpn
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Hosoya Osamu
Research Institute Of Tts Technology Josai University
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Juni K
Faculty Of Pharmaceutical Sciences Josai University
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Juni Kazuhiko
北海道薬科大学
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Juni Kazuhiko
Faculty Of Pharmaceutical Sciences Hokkaido University
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Seki T
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
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Seki Toshinobu
Hokkaido Pharmaceutical University School Of Pharmacy
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Okamoto M
Department Of Pharmacology The University Of Tokushima School Of Medicine
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Seki T
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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Seki T
Hokkaido Pharmaceutical University School Of Pharmacy
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OKAMOTO Maiko
Faculty of Pharmaceutical Sciences, Josai University
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岡本 麻衣子
城西大学
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Morimoto Kazuhiro
Department Of Pharmaceutics Graduate School Of Pharmaceutical Sciences Hokkaido Pharmaceutical Unive
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Morimoto K
Hokkaido Pharmaceutical University School Of Pharmacy
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