Studies on Agents with Vasodilator and β-Blocking Activities. III. Synthesis and Activity of Optical Isomers of TZC-1370
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概要
- 論文の詳細を見る
Optical isomers of TZC-1370 (1) were prepared from (R)- and (S)-1-(2-chlorophenoxy)-2,3-epoxypropane. When given intravenously to anesthetized rats, the (S)-isomer was about 40 times more potent in terms of β-blocking activity than the (R)-isomer, while their hypotensive activities were equipotent with that of the racemic compound, TZC-1370.
- 社団法人日本薬学会の論文
- 1995-10-15
著者
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石森 勉
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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安田 喜久男
Research Laboratory, Teikoku Hormone Mfg. Co., Ltd.
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安田 喜久男
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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関 敏美
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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竹崎 孝行
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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大内 力男
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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斎藤 守信
Research Division, Teikoku Hormone Manufacturing Co., Ltd.,
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Seki Taiichiro
Lab. Of Nutrition And Physiology Dep. Of Chemistry And Life Sci. Nihon Univ. Coll. Of Bioresource Sc
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Seki T
Department Of Nutrition And Physiology Nihon University College Of Bioresource Sciences
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関 敏美
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Saitoh Makiko
Faculty Of Pharmaceutical Sciences Kanazawa University
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大内 力男
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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竹崎 孝行
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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斎藤 守信
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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Yamashita K
Faculty Of Pharmaceutical Sciences Okayama University
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