Synthesis of Some 3,5-Diene-2,7-dioxosteroids
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概要
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tert-Butyl chromate oxidation of some steroidal 3,5-dienes was examined. The oxidation proceeded first at C-7 and then at C-2 irrespective of what substituent was at C-3. Thus some 3,5-diene-2,7-diones were obtained by reoxidation of 3,5-dien-7-one. 1,6-Addition of methylmagnesium iodide to 17β-acetoxyandrosta-3,5-dien-7-one afforded 17β-hydroxy-3α-methylandrost-4-en-7-one, which was converted to 17β-acetoxy-3α-methyl-androst-5-en-7-one by treatment with acetic acid and concentrated hydrochloric acid. Similarly 17β-acetoxy-3,3-dimethylandrost-5-en-7-one was obtained from 17β-acetoxy-3-methylandrosta-3,5-dien-7-one.
- 社団法人日本薬学会の論文
- 1967-02-25
著者
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森 弘
Chemical Research Department Teikoku Hormone Mfg. Co. Ltd.
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森 弘
Research Laboratory, Teikoku Hormone Mfg. Co., Ltd., Shimosakunobe, Kawasaki
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安田 喜久男
Research Laboratory, Teikoku Hormone Mfg. Co., Ltd.
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安田 喜久男
Research Division Teikoku Hormone Manufacturing Co. Ltd.
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