Studies on Steroidal Compounds. VI. Grignard Reaction of 19-Nor-4-en-3-oxo-steroids.
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概要
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The Grignard reaction of 17β-hydroxy-17α-methylestr-4-en-3-one (VIIa) in the presence of cuprous chloride gave 5β, 17α-dimethyl-17β-hydroxyestran-3-one (VIIIa) and 3,17α-dimethylestra-3,5-dien-17β-ol (Xa). Similarly, (VIIIb) and (Xb) were obtained by the Grignard reaction of 17β-hydroxyestr-4-en-3-one (VIIb). The oxidation of (VIIIb) with chromium trioxide gave 5β-methyl-estrane-3,17-dione (XI). Discussion was made on the configuration of C-5 methyl group in (VIIIa) and (VIIIb).
- 公益社団法人日本薬学会の論文
- 1962-05-25
著者
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森 弘
Chemical Research Department Teikoku Hormone Mfg. Co. Ltd.
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森 弘
Research Laboratory, Teikoku Hormone Mfg. Co., Ltd., Shimosakunobe, Kawasaki
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