Studies on Steroidal Compounds. XII. Stereochemistry of 1,4-Addition of Grignard Reagent for α, β-Unsaturated Steroidal Ketones. Grignard Reaction of 3β-Hydroxycholest-4-en-6-one
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概要
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The Grignard reaction of 3β-hydroxycholest-4-en-6-one (V) was undertaken in the presence of cuprous chloride or cupric acetate. 1,4-Addition product was isolated, and its structure was proved to be 3β-hydroxy-4β-methyl-5α-cholestan-6-one (VI). Some transformations related to this compound were made. From observations of the Grignard reaction and other reactions of α, β-unsaturated steroidal ketones reported in literature, it may be concluded that the configuration of alkyl group newly introduced by 1,4-addition should be axially oriented.
- 公益社団法人日本薬学会の論文
- 1964-10-25
著者
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森 弘
Chemical Research Department Teikoku Hormone Mfg. Co. Ltd.
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森 弘
Research Laboratory, Teikoku Hormone Mfg. Co., Ltd., Shimosakunobe, Kawasaki
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