Studies on Steroidal Compounds. IV. Synthesis of 6-Alkoxy-3-oxo-4,6-diene Steroidal Hormones.
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概要
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Synthesis of some steroidal hormones having 6-alkoxy-4,6-dien-3-one structure was carried out. 17β-Acetoxyandrost-4-ene-3,6-dione (V), prepared by oxidation with chromium trioxide of 6β-hydroxy-17β-acetoxyandrost-4-en-3-one (VI), was treated with ethanol and p-toluenesulfonic acid monohydrate to give 6-ethoxy-17β-acetoxyandrosta-4,6-dien-3-one (VI). The treatment of 17α-acetoxypregn-4-ene-3,6,20-trione (X) with ethanol (or methanol) and p-toluenesulfonic acid monohydrate gave 6-ethoxy-(or methoxy)-17α-acetoxypregna-4,6-diene-3,20-dione (XIa or XIb). (X) was synthesized from 17α-acetoxypregn-4-ene-3,20-dione (VII) by the modified method of Romo.
- 公益社団法人日本薬学会の論文
- 1961-04-25
著者
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森 弘
Chemical Research Department Teikoku Hormone Mfg. Co. Ltd.
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森 弘
Research Laboratory, Teikoku Hormone Mfg. Co., Ltd., Shimosakunobe, Kawasaki
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