Preparations of Some Steroidal Diosphenols.
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概要
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Some 4,4-dimethyl-2-hydroxy-⊿^1-3-one type steroids (diosphenols) were prepared as potential tumor growth inhibiting chemotherapeuticals modeled on the cancer inhibiting elatericin B. These substances were obtained from 4,4-dimethyl-3-oxo steroids by selenium dioxide oxidation, by a method via the 2-bromo compound, by a method via the 2-oximino compound or by autooxidation. The last two procedures were found to be the most suitable for the preparation of the desired substances. The diosphenols we obtained were as follows : 2-hydroxylanosta-1,8,24-trien-3-one (VIa), 2-hydroxylanosta-1,8-dien-3-one (VIb), 2-hydroxy-3-oxo-4,4,14α-trimethyl-⊿^<1,8>-5α-choladienic acid (VId), 2,17β-dihydroxy-4,4-dimethylandrosta-1,5-dien-3-one (XVIa), 2-hydroxy-4,4-dimethyl-22α-spirosta-1,5-diene-3-one (XVIc), 3-oxo-2,12α-dihydroxy-4,4-dimethyl-⊿^<1,5>-choladienic acid (XXIa), 2-hydroxy-3,12-dioxo-4,4-dimethyl-⊿^<1,5>-choladienic acid (XXVa), and 2-hydroxy-4,4-dimethylergosta-1,5,7,22-tetraen-3-one (XXVIII). 4-Hydroxy-3,12-dioxo-⊿^4-cholenic acid (XXVII) was also prepared.
- 公益社団法人日本薬学会の論文
- 1962-09-25
著者
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森 弘
Chemical Research Department Teikoku Hormone Mfg. Co. Ltd.
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森 弘
Worcester Foundation for Experimental Biology
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ビピチャンドラ・エス ガンジ
Worcester Foundation for Experimental Biology
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アーヴィン シュベング
Worcester Foundation for Experimental Biology
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