Homogeneity and Multiplicity Forms of Glandular Kallikreins

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概要

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• Three preparations of hog pancreatic kallikrein (Hog Panc. K.) were applied to Ampholine isoelectric focusing. Each of them were separated into 5-6 kallikrein components with slightly different pI's in the range of pH 3.7-4.2. The migration distances of these components in disc electrophoresis (pH 8.9,7% polyacrylamide gel) were not distinguishable. Relating to these results, it was suggested that isoelectric focusing or gel isoelectrofocusing would be preferable to disc electrophoresis for the examination of the real homogeneity of Hog Panc. K. and other glandular kallikreins. It was found by isoelectric focusing that human urinary kallikrein consisted of 3-5 components with pI 3.8-4.3. On the other hand, human salivary kallikrein seemed to be composed of one component with pI 4.2.

• 社団法人日本薬学会の論文
• 1975-05-25

著者

• 森 弘

  Chemical Research Department Teikoku Hormone Mfg. Co. Ltd.

• 法島 義男

  Faculty of Pharmaceutical Sciences Science University of Tokyo

• 森脇 千秋

  Faculty of Pharmaceutical Sciences Science University of Tokyo

• 森 弘

  Faculty of Pharmaceutical Sciences Science University of Tokyo

• 松田 兆史

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 森脇 千秋

  Laboratory Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 松田 兆史

  Department of Biochemistry

• 法島 義男

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo:(present Address)department Of Immuno

• 森脇 千秋

  Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo

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