ブタ膵臓性キニノゲナーゼの降圧作用と血漿キニノーゲンにおよぼす影響

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概要

• 論文の詳細を見る

• The effects of hog pancreatic kininogenase (Hog Panc. K.) on blood pressure and plasma kininogen level in normal and renal hypertensive rabbits were studied. Intramuscular injection of Hog Panc. K. resulted in a dose-dependent vasodepressor action in normal rabbits, and this action was more pronounced in renal hypertensive rabbits. Intravenous, intramuscular and intraduodenal administration of Hog Panc. K. led to the consumption of plasma kininogen in normal rabbits, however, their total plasma protein levels did not change. Both the vasodepressor response and the consumption of plasma kininogen by Hog. Panc. K. seemed to be dose-dependent in renal hypertensive rabbits. In renal hypertensive rabbits the level of plasma kininogen was 1.7 times higher than in normal rabbits, while the vasodepressor effect of Hog Panc. K. did not appear in spontaneously hypertensive rats. Kinin formation by various kininogenases from plasma kininogen obtained from various animals was also examined. Hog Panc. K. caused a kinin-liberation from the crude kininogen preparations obtained from human, bovine, hog, dog and rabbit plasma, but not from that of guinea pig and rat.

• 社団法人日本薬学会の論文
• 1979-01-25

著者

• 森脇 千秋

  Laboratory Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo

• 森脇 千秋

  東京理科大学薬学部

• 末永 栄一

  (株)三和化学研究所 製薬薬理研究所

• 鈴木 常正

  (株)三和化学研究所 三重研究所

• 森脇 千秋

  Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo

関連論文

• Isolation of Dog, Rat and Hog Pancreatic Kallikreins by Preparative Disc Electrophoresis and Their Properties
• Homogeneity and Multiplicity Forms of Glandular Kallikreins
• Studies on Kallikreins. VII. Effects of Kallikrein and Some Autacoids on in Vitro Transport of Valine and Sodium Ion
• Studies on Kallikreins. VI. Effect of Pancreatic Kallikrein and Kinin on the Transport of Amino Acids and Glucose across the Rat Small Intestine
• Studies on Kallikreins. V. Purification and Characterization of Rat Intestinal Kallikrein
• Kinin-Converting Activity in the Dog Pseudoglobulin Fraction from Heated Plasma and Kinin Liberation from Dog Kininogen by Guinea-pig Coagulating Gland Kallikrein (CGK)
• Kinin-Inactivating Enzyme from the Mushroom Tricholoma conglobatum. V. Its Application to Anaphylactic Shock in Rats
• Kinin-inactivating Enzyme from the Mushroom Tricholoma conglobatum. IV. Its Effects on the Kallikrein-Kinin System
• ビート(Beta vulgaris L. var. rapa DUMORT.f.rubra DC.)中の抗キニン作用物質の性質について
• Kinin Inactivating Enzyme from Mushroom Tricholoma conglobatum. III. Stability in the Rat Body and Kinin Suppression in Vivo
• Kinin Inactivating Enzyme from Mushroom Tricholoma conglobatum. II. Some Enzymatic Properties of the Purified Enzyme
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