Kinin-Inactivating Enzyme from the Mushroom Tricholoma conglobatum. V. Its Application to Anaphylactic Shock in Rats

概要

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In order to clarify the involvement of the kallikrein-kinin system in anaphylactic shock, Shimeji kininase, which is able to block kinin action in the body due to rapid kinin destruction, was tested on anaphylactic shock in rats. The anaphylactic shock in rats at 15 days after sensitization with egg albumin was hardly suppressed by Shimeji kininase alone or mepyramine alone, but the rats were markedly protected when this enzyme was used together with mepyramine. The rats at 30 days after sensitization were completely protected against shock by mepyramine alone and were also protected to some extent by Shimeji kininase alone. Thus, at the early phase after sensitization, both kinins and histamine appear to play important roles in anaphylaxis in rats, but in the late phase after sensitization, histamine is considered to play a more important role than kinins. In the rats at 15 days after sensitization, the high molecular weight kininogen level in plasma did not alter on challenge with antigen, and plasma prekallikrein activation was not detected. On the other hand, a slight but significant decrease of low molecular weight kininogen level and an increase of kinin level on challenge with antigen were observed.
社団法人日本薬学会の論文
1979-10-25