カリクレインのラット神経幹細胞増殖促進作用
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概要
- 論文の詳細を見る
Tissue kallikrein is expressed in many species and is widely distributed throughout the body, including the brain. In general, this protease is well known to release the vasoactive peptide, kinin, from kininogen. We report here that kallikrein has a prominent growth-stimulating effect on neural stem cells prepared from the brains of prenatal rats. This growth-stimulating effect was suppressed by antiserum against rat tissue kallikrein. Since bradykinin B_2-receptor antagonist, Hoe140, did not suppress the growth-stimulating effect, kallikrein-mediated kinin release does not appear to be involved in this effect. Thus, our data suggest a new physiological function of kallikrein, the growth of neural stem cells. Such involvement would suggest that kallikrein is not only potentially involved in an important function of brain development, but also available for studies on regenerative medicine for neurons.
- 公益社団法人日本薬学会の論文
- 2006-10-01
著者
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木付 和幸
山口東京理大 基礎工
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木付 和幸
Department Of Materials Science And Environmental Engineering Faculty Of Science And Engineering Tok
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岩館 寛大
山口東京理大 基礎工
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大久保 隆一
山口東京理科大学基礎工学部,物質・環境工学科
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貞 啓介
山口東京理科大学基礎工学部,物質・環境工学科
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貞 啓介
山口東京理科大学基礎工学部 物質・環境工学科
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大久保 隆一
Department Of Materials Science And Environmental Engineering Faculty Of Science And Engineering Tok
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岩館 寛大
Department Of Materials Science And Environmental Engineering Faculty Of Science And Engineering Tok
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木付 和幸
山口東京理科大学、基礎工学部、物質・環境工学科
関連論文
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- カリクレインのラット神経幹細胞増殖促進作用