Growth-stimulating Effect of Kallikrein on Rat Neural Stem Cells : II. Immunocytochemical Analysis and Specificity of the Enzyme for Neural Stem Cells

スポンサーリンク

概要

• 論文の詳細を見る

• In a previous paper we reported a new function of tissue kallikrein: rat urinary kallikrein (RUK) has a marked growth-stimulatory effect on neural stem cells prepared from brains of prenatal rats. We here report that conspicuous differentiation of neural stem cells to neurons and/or glial cells did not occur during stimulation by kallikrein, and this growth-stimulating effect of kallikrein is considerably specific for neural stem cells, i.e., RUK showed no detectable stimulatory effect on rat glial, PC 12, GH_3, and HeLa cells. Thus this new function of kallikrein suggests the potential involvement of this enzyme on brain physiology. In addition, this effect of kallikrein for neural stem cells may have value in the treatment of cerebral ischemic stroke-induced injuries etc., i.e., kallikrein administered into the body stimulates neural stem cell proliferation and new neurons may be generated from them.

• 公益社団法人日本薬学会の論文
• 2007-05-01

著者

• 木付 和幸

  Department of Biochemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 木付 和幸

  山口東京理大 基礎工

• 木付 和幸

  Department Of Materials Science And Environmental Engineering Faculty Of Science And Engineering Tok

• 岩館 寛大

  Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, T

• 大久保 隆一

  Department of Materials Science and Environmental Engineering, Faculty of Science and Engineering, T

• 大久保 隆一

  Department Of Materials Science And Environmental Engineering Faculty Of Science And Engineering Tok

• 岩館 寛大

  Department Of Materials Science And Environmental Engineering Faculty Of Science And Engineering Tok

• 木付 和幸

  山口東京理科大学、基礎工学部、物質・環境工学科

関連論文

• The Carbohydrate Moiety of Human Urinary Kallikrein
• Kinin-Converting Activity in the Dog Pseudoglobulin Fraction from Heated Plasma and Kinin Liberation from Dog Kininogen by Guinea-pig Coagulating Gland Kallikrein (CGK)
• Kinin-Inactivating Enzyme from the Mushroom Tricholoma conglobatum. V. Its Application to Anaphylactic Shock in Rats
• Kinin-inactivating Enzyme from the Mushroom Tricholoma conglobatum. IV. Its Effects on the Kallikrein-Kinin System
• Kinin Inactivating Enzyme from Mushroom Tricholoma conglobatum. III. Stability in the Rat Body and Kinin Suppression in Vivo
• Kinin Inactivating Enzyme from Mushroom Tricholoma conglobatum. II. Some Enzymatic Properties of the Purified Enzyme
• Studies on Kallikreins. IV. Enhancement of Valine Transport Across the Rat Small Intestine
• Kinin Inactivating Enzyme from Mushroom Tricholoma conglobatum. I. Purification and the Sites of Action on Bradykinin Molecule
• コンゴーレッドエラスチンを用いるエラスターゼの改良活性測定法
• Generation of a Different Type of β-Kallikrein from Porcine Pancreatic α-Kallikrein by the Action of Chymotrypsin : Observation of Proteolytic Processing Occurring around "Kallikrein Autolysis Loop" Region
• Generation of α- and β-Kallikreins from Porcine Panceratic Prokallikrein by the Action of Trypsin
• Human Urinary Kallikrein. II. Analysis of Asparagine-Linked Oligosaccharides by Using Lectins(Biological)
• Angiotension I Converting Enzymes in Rat Epididymis
• 膵臓性エラスターゼの酵素化学的研究(第3報)血液中に移行する膵臓由来の前駆体様エラスターゼについて
• ラット精巣に存在するアンジオテンシンI-変換酵素の酵素学的性質 : ラット肺酵素との比較検討
• Procine Pancreatic Prokallikrein. III. Some Different Forms of Kallikrein Generated from Prokallikrein
• 膵臓性エラスターゼの酵素化学的研究(第2報)ブタ膵臓性エラスターゼIのフィブロネクチン水解作用について
• Immunological Relationships of the Glandular Kallikreins
• Porcine Pancreatic Prokallikrein. II. Purification and Some Properties of Prokallikrein A
• Porcine Pancreatic Prokallikrein. I. Its Partial Purification and Effects of Various Proteases on Its Activation
• Studies on Heterogeneous Components of Hog Pancreatic Kallikrein. II. Preliminary Probe of the Varied Structures of Carbohydrate Chain of Hog Pancreatic Kallikrein
• Studies on Heterogeneous Components of Hog Pancreatic Kallikrein : "Possible Role of the Neuraminic Acid Residues"
• Measurement of Carbohydrate Contents in Multiple Forms of Hog Pancreatic Kallikrein and Their Behavior on Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis
• トウモロコシferredoxin thioredoxin reductase(FTR)のサブユニット間結合部位の決定
• Porcine Pancreatic Prokallikrein. IV. : N-Terminal Amino Acid Sequences of Prokallikrein B and the Kallikrein Generated from It by the Action Trypsin
• A New Potent Kinin-inactivating Enzyme from the Mushroom Psalliota hortensis
• Kinin-inactivating Enzyme from the Mushroom Tricholoma conglobatum. VII. Suppression of Epinephrine-induced Pulmonary Edema in Rats
• Kinin-inactivating Enzyme from the Mushroom Tricholoma conglobatum. VI. Actions on Angiotensins I and II
• Growth-stimulating Effect of Kallikrein on Rat Neural Stem Cells : II. Immunocytochemical Analysis and Specificity of the Enzyme for Neural Stem Cells
• カリクレインのラット神経幹細胞増殖促進作用

もっと見る 閉じる

スポンサーリンク