Studies on Kallikreins. VII. Effects of Kallikrein and Some Autacoids on in Vitro Transport of Valine and Sodium Ion
スポンサーリンク
概要
- 論文の詳細を見る
The effect of kallikrein and some autacoids on the transport and uptake of valine in the rat small intestine was examined, in vitro, by the method of sac of everted in testine and by measurement of uptake of valine in the tissue. Kallidin and rat intestinal kallikrein (RIK) stimulated the intestinal transport of valine, like bradykinin and pancreatic kallikrein. Kallidin was more effective than bradykinin or Met-Lys-bradykinin. RIK stimulated the transport significantly when it was added to either the mucosal or serosal side. Moreover, the accumulation of valine into the small intestine was enhanced by bradykinin, and a similar result was obtained by the combined addition of rat pancreatic kallikrein and rat kininogen to the medium. The net mucosa-to-serosa Na^+ transport was enhanced by the addition of bradykinin to the serosal side of the everted intestine, and Na^+ transport was further increased by adding bradykinin to the serosal fluid and glucose to the mucosal. The net Na^+ transport was suppressed by the addition of ouabain in the serosal fluid, but was restored to the normal level by bradykinin. Measurement of Na^+ in the intestine showed that addition of bradykinin to the medium reduced the uptake of Na^+ into the tissue and enhanced the efflux of Na^+ from the intestine to the medium. Glucose- or valine-evoked transmural potential difference in jejunum segment was elevated by the addition of kallidin to the serosal side, but the transepithelial resistance was not altered. Thus, we suggest that Na^+ transport in the small intestine is stimulated by the action of kinins on the serosal side of the intestine, and this acceleration of Na^+-flux seems to be accompanied with the enhancement of amino acid and glucose transport.
- 社団法人日本薬学会の論文
- 1982-01-25
著者
-
藤森 広幸
Laboratory Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
森脇 千秋
Laboratory Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
-
浜野 修一郎
Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tok
-
浜野 修一郎
Laboratory Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
関連論文
- Isolation of Dog, Rat and Hog Pancreatic Kallikreins by Preparative Disc Electrophoresis and Their Properties
- Homogeneity and Multiplicity Forms of Glandular Kallikreins
- Studies on Kallikreins. VII. Effects of Kallikrein and Some Autacoids on in Vitro Transport of Valine and Sodium Ion
- Studies on Kallikreins. VI. Effect of Pancreatic Kallikrein and Kinin on the Transport of Amino Acids and Glucose across the Rat Small Intestine
- Studies on Kallikreins. V. Purification and Characterization of Rat Intestinal Kallikrein
- Kinin-Converting Activity in the Dog Pseudoglobulin Fraction from Heated Plasma and Kinin Liberation from Dog Kininogen by Guinea-pig Coagulating Gland Kallikrein (CGK)
- Kinin-Inactivating Enzyme from the Mushroom Tricholoma conglobatum. V. Its Application to Anaphylactic Shock in Rats
- Kinin-inactivating Enzyme from the Mushroom Tricholoma conglobatum. IV. Its Effects on the Kallikrein-Kinin System
- ビート(Beta vulgaris L. var. rapa DUMORT.f.rubra DC.)中の抗キニン作用物質の性質について
- Kinin Inactivating Enzyme from Mushroom Tricholoma conglobatum. III. Stability in the Rat Body and Kinin Suppression in Vivo
- Kinin Inactivating Enzyme from Mushroom Tricholoma conglobatum. II. Some Enzymatic Properties of the Purified Enzyme
- ブタ膵臓性キニノゲナーゼの降圧作用と血漿キニノーゲンにおよぼす影響
- Measurement of the Sugar Contents and Their Effect on the Electrophoretical Behaviors of Multiple Forms of Hog Pancreatic Kallikrein
- ビタミンB_2の腸管吸収に関する研究
- Studies on Kallikreins. IV. Enhancement of Valine Transport Across the Rat Small Intestine
- Kinin Inactivating Enzyme from Mushroom Tricholoma conglobatum. I. Purification and the Sites of Action on Bradykinin Molecule
- Studies on Proteinases from Ficus carica var. HORAISHI. VI. Immunochemical Comparison of Ficins A, B, C, D and S
- Anti-Bradykinin Activity Found in Beet (Beta vulgaris L. var. rapa DUMORT. f. rubra DC.)
- Aspergillus Proteinaseに関する研究(第8報)Aspergillus melleusの産生する微アルカリプロティナーゼの腸管吸収
- Studies on Kallikreins. III. Intra-intestinal Administration of Hog Pancreatic Kallikrein and Its Appearance in the Perfusate from the Mesenteric Vein
- Studies on the Passage of α-Chymotrypsin across the Intestine. III. Quantitation of α-Chymotrypsin in the Mesenteric Perfusate by Single Radial Immunodiffusion
- Studies on the Passage of α-Chymotrypsin across the Intestine. II. Enzymic Activity and Radioactive Macromolecule recovered in the Mesenteric Perfusate
- A Proposal-Use of Combined Assays of Kallikrein Activity Measurement
- Studies on the Passage of α-Chymotrypsin across the Intestine.
- Further Purification and Properties of Kininogenase from the Guinea Pig's Coagulating Gland