Studies on Kallikreins. III. Intra-intestinal Administration of Hog Pancreatic Kallikrein and Its Appearance in the Perfusate from the Mesenteric Vein
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概要
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The perfusion of the mesenteric vascular system with Krebs-Ringer solution was carried out on the rats, and the vasodilator and BAEE-esterolytic activities in the perfusate were determined after the intestinal administration of hog pancreatic kallikrein. The recoveries of both kallikrein activities agreed well with each other and with that of ^<131>Imacromolecules in the case of a combined administration of ^<131>I-kallikrein. The transmission of kallikrein through the intestine seemed to reach its maximum within 30 min after the administration and it diminished rapidly thereafter. The mesenteric perfusate formed a few precipitin bands against the anti-kallikrein rabbit serum on the double immunodiffusion, and one of them was also positive in the activity-staining utilizing BAEE-esterolytic activity. These results suggest that the pancreatic kallikrein is transmitted from the intestine to the vascular system, maintaining its enzymic properties and its immunoreactivity and that about 1% of the given kallikrein seems to be absorbed into the mesenteric vein under this experimental condition.
- 社団法人日本薬学会の論文
- 1974-09-25
著者
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山口 稽子
東京理科大学薬学部
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森脇 千秋
Laboratory Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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守屋 寛
Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tok
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山口 稽子
Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tok
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森脇 千秋
Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tokyo
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