Studies on the Passage of α-Chymotrypsin across the Intestine.
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概要
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^<131>I-labelled α-chymotrypsin was administered into the ligated intestine of adult rats, and ^<131>I distribution was studied. Differences were found in the distribution in the kidney from the control experiment of ^<131>I-KI administration in the same way. Furthermore, ^<131>I-bound protein was surely observed in the serum after the intraintestinal administration of ^<131>I-labelled α-chymotrypsin was comparatively stable in natural human intestinal and gastric juices under the addition of 0.033M Ca ion, but without Ca ion, it was rapidly degraded and lost its esterase activity with both juices. In in vitro experiment with the sac of everted intestine of rats, it was found that chymotrypsin was transferred from the mucosal to the serosal side with its esterase activity. From these experimental results, the possibility of the transfer of α-chymotrypsin across the intestine was discussed.
- 公益社団法人日本薬学会の論文
- 1967-11-25
著者
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山口 稽子
東京理科大学薬学部
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森脇 千秋
Laboratory Of Physiological Chemistry Faculty Of Pharmaceutical Sciences Science University Of Tokyo
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守屋 寛
Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tok
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山口 稽子
Laboratory of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Science University of Tok
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秋元 節子
東京理科大学薬学部生生理化学
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岩垂 正矩
東京理科大学薬学部生生理化学
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秋元 節子
Laboratory of Physiological Chemistry, Science University of Tokyo, Faculty of Pharmaceutical Scienc
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岩垂 正矩
Laboratory of Physiological Chemistry, Science University of Tokyo, Faculty of Pharmaceutical Scienc
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