Studies on Kallikreins.II.Passage of ^<131>I-Labelled Hog Pancreatic Kallikrein across the Rat Intestine

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概要

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• The hog pancreatic kallikrein was labelled with radioactive iodine (^<131>I) and was administered to rats in the tied loop of the jejunum. Relatively high distribution of radioactivity was found in the kidney and the liver and the existence of the ^<131>I-labelled macromolecules in serum was also observed after the intraintestinal administration of ^<131>I-kallikrein. The sac of everted jejunum was incubated in the Krebs-Ringer bicarbonate buffer containing ^<131>-kallikrein and itwas observed that the radioactive macromolecule having the vasodilator activity was transferred to the serosal side from the mucosal side. From these results, the possibility of the intestinal absorption of pancreatic kallikrein was discussed.

• 公益社団法人日本薬学会の論文
• 1967-04-25

著者

• 森脇 千秋

  Faculty of Pharmaceutical Sciences Science University of Tokyo

• 秋元 節子

  Faculty of Pharmaceutical Sciences, Science University of Tokyo

• 秋元 節子

  東京理科大学薬学部生生理化学

• 守屋 寛

  Faculty Of Pharmaceutical Science Science University Of Tokyo

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