Studies on Kallikrein Inhibitors from Potatoes. III. Some Pharmacological Actions of Potato-Kallikrein-Inhibitors (PKI)

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概要

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• Potato-kallikrein-inhibitors (PKI) showed the anti-inflammatory potency in rat carrageenin edema and reduced the exudation of leucocytes into carboxymethylcellulose pouch in the dorsum of rats, but not the protein exudation. PKI was not effective against egg white edema, which was depressed by α-chymotrypsin to some extent. PKI showed the inhibitory action on the release of vasodilative substances produced from rat serum (pH 4) and human plasma (pH 5) by acidification in vitro, which might be the products (kinin- and kallikrein-like, respectively) from the activation of kallikreinkinin system. PKI also inhibited the acetone activation of human plasma. These inhibitory actions of PKI were stronger than Trasylol using equal kallikrein inhibitor units. In the rat anaphylactic shock provoked by challenging with horse serum as antigen, PKI, Trasylol, soybean trypsin inhibitor and other tested substances for the inhibition of anaphylaxis did not show the definite effectiveness on the survival rate of rats.

• 公益社団法人日本薬学会の論文
• 1972-06-25

著者

• 森脇 千秋

  Faculty of Pharmaceutical Sciences Science University of Tokyo

• 法島 義男

  Faculty Of Pharmaceutical Sciences Science University Of Tokyo:(present Address)department Of Immuno

• 田島 鉄弥

  Laboratory Of Pharmacology Eisai Co. Ltd.

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