ヒト尿由来Kallidinogenase(SK-827)の薬理学的研究 : 脳機能保護作用

概要

論文の詳細を見る
We investigated the cerebral protective effects of human urinary kallidinogenase (SK-827) in rabbits. The following results were obtained : 1) At a dose of 5.0×10^<-3> to 1.25×10^<-2> PNA U/kg, SK-827 significantly inhibited the decrease of focal cerebral blood flow and the impairment of electrocorticogram (ECoG) activity in infarcted rabbits. 2) SK-827 at a dose of 2.5×10^<-3> PNA U/kg inhibited the development of infarction area induced by internal carotid arterial injection of glass beads. 3) SK-827 at a dose of 2.5×10^<-3> to 5.0×10^<-3> PNA U/kg inhibited the decrease of cerebral cortical pO_2 induced by 5% oxygen inhalation. 4) On subacute phase 7 days after the destruction of internal capsule, SK-827 at a dose of 1.25×10^<-2> PNA U/kg improved the abnormality of spontaneous ECoG. These findings suggest that SK-827 minimizes the reduction of cerebral function induced by ischemia.
社団法人日本薬学会の論文
1993-11-25