吸収排泄におよぼす医薬品の併用効果(第14報)家兎におけるSulfisomidineの消化管吸収におよぼすAtropineの影響
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The effect of atropine on the gastrointestinal absorption of sulfisomidine was investigated in rabbits. Atropine reduced the maximum blood concentration (C_<max>) of sulfisomidine, and prolonged the time taken to reach the maximum blood concentration (T_<max>) of sulfisomidine. However, atropine had no effect on the area under blood concentration-time curve (AUC) and the elimination half-life (t_<1/2>) of sulfisomidine. In addition, atropine delayed the gastric emptying rate, but did not change the dissolution rate and the intestinal membrane permeability of sulfisomidine. These results led us to conclude that atropine affects the rate but not the extent of the gastrointestinal absorption of sulfisomidine, by delaying the gastric emptying rate.
- 公益社団法人日本薬学会の論文
- 1982-10-25
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