Studies on Synthetic Sweetening Agents. XVII. Metabolism of Sodium Cyclamate. (6). Influences of Neomycin and Sulfaguanidine on Metabolism of Sodium Cyclamate
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概要
- 論文の詳細を見る
For the purpose of elucidating the metabolic sites of sodium cyclamate (CHS-Na), the influences of neomycin and sulfaguanidine on the metabolism of CHS-Na were investigated in rabbits, rats, and mice. Neomycin and sulfaguanidine caused a conspicuous decrease in the urinary excretion of CHS-Na metabolites in rats and mice. However the excretion of CHS-Na metabolites in rabbits did not decrease by administration of neomycin or sulfaguanidine. Also, CHS-Na metabolites were found in the urine of rabbits and rats following intravenous dose of CHS-Na. These results demonstrate that the metabolism of CHS-Na in the rat and mouse is predominantly carried out in the intestines, probably by the microbial flora, and that CHS-Na metabolism in the rabbit takes place mainly in the liver.
- 社団法人日本薬学会の論文
- 1972-07-25
著者
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児島 昭次
Dept. Of Hygienic Chem. Fac. Pharm. Sci. Kumamoto Univ.
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児島 昭次
Faculty Of Pharmaceutical Sciences Kumamoto University
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末永 綾香
Faculty Of Pharmaceutical Sciences Kumamoto University
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一番ケ瀬 尚
Faculty of Pharmaceutical Sciences, Kumamoto University
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一番ケ瀬 尚
熊本大薬
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一番ケ瀬 尚
Faculty Of Pharmaceutical Sciences Kumamoto University
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