ヘテロ環化合物の研究(第2報) : プリンおよびピリミジン誘導体の非水滴定における半中和点電位差とpKa(H_2O)の関係

概要

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Half-neutralization potentials (HNP) of non-aqueous titration of 22 pyrimidine derivatives and 10 purine derivatives have been set against pKa (H_2O) values determined by spectrophotometry. Linear relationship exists between HNP and pKa of most of the pyrimidine and purine derivatives (Figs. 3 and 4), and pKa values calculated with the algebraic expression of these relations (formulas 1-7), using the observed non-aqueous HNP values, correspond with the spectrophotometric pKa data with the error limit of ±0.5 (Tables I-V). Methylcellosolve-acetonitrile mixture shows greater resolving power than acetic acid-acetic anhydride mixture as non-aqueous solvent for the potentiometric titration of pyrimidine and purine derivatives with perchloric acid.
公益社団法人日本薬学会の論文
1966-07-25