有害性金属に関する研究(第3報)ラットにおける塩化カドミウムの消化管吸収, 分布および排泄に及ぼすキレート剤の影響

概要

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The effect of various chelating agents on the gastrointestinal absorption, distribution, and excretion of cadmium was studied in rats. 1) During a single oral administration of cadmium chloride and chelating agents, ethylenediaminetetraacetic acid (EDTA) and citric acid enhanced the gastrointestinal absorption of cadmium and increased the urinary excretion of the metal. 2) In continuous oral dosings of cadmium chloride agents such as EDTA, citric acid, and L-ascorbic acid, the effect of these chelating agents on cadmium accumulation in rat organs was not so conspicuous. 3) After termination of the repeated oral dosings of cadmium chloride to rats for 30 days, the chelating agents such as EDTA, 2,3-dimercapto-1-propanol (BAL), citric acid, and L-ascorbic acid were administered orally and continuously to the rats for 30 days. EDTA increased the urinary excretion and accumulation of cadmium in the kidneys. Other chelating agents had little effect on the tissue distribution and urinary excretion of cadmium.
公益社団法人日本薬学会の論文
1977-02-28