Alkylnaphthalenes. I. : Absorption, Tissue Distribution and Excretion of 2,6-Diisopropylnaphthalene in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Upon a single oral administration of 2,6-DIPN (100mg/kg) to rats, about 85% of the dose was absorbed from the gastrointestinal tract during 48 hr after the administration. Only a small amount of unchanged 2,6-DIPN was excreted in urine. The maximum levels of 2,6-DIPN in the liver, kidney, heart, spleen, brain and muscle were obtained within 4 hr after the administration and then the levels decreased with time. However, the time for reaching the maximum level of 2,6-DIPN in the skin and adipose tissue was longer than that in the other tissues. In addition, the content and disappearance of 2,6-DIPN in the adipose tissue were higher and slower than those in the other tissues.
- 公益社団法人日本薬学会の論文
- 1978-10-25
著者
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児島 昭次
Dept. Of Hygienic Chem. Fac. Pharm. Sci. Kumamoto Univ.
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児島 昭次
Faculty Of Pharmaceutical Sciences Kumamoto University
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児島 昭次
熊本大学薬学部
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鈴木 立子
Faculty Of Pharmaceutical Sciences Kumamoto University
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中川 満夫
Faculty of Pharmaceutical Sciences, Kumamoto University
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中川 満夫
Faculty Of Pharmaceutical Sciences Kumamoto University
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堀尾 美智子
Faculty of Pharmaceutical Sciences, Kumamoto University
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田中 洋子
Faculty of Pharmaceutical Sciences, Kumamoto University
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堀尾 美智子
Faculty Of Pharmaceutical Sciences Kumamoto University
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田中 洋子
Faculty Of Pharmaceutical Sciences Kumamoto University
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